骨质疏松性椎体压缩骨折的Micro-CT影像学参数分析

发布时间：2018-03-06 00:06

  本文选题：骨质疏松　切入点：椎体压缩骨折　出处：《中国骨质疏松杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的初步探讨骨质疏松性椎体压缩骨折患者、骨质疏松患者以及无骨质疏松患者3者间椎体骨质的差别。方法对30例需要进行手术治疗的患者进行分组,分别为骨质疏松性椎体压缩骨折患者组、骨质疏松患者组及无骨质疏松患者组,每组10例。在术中分别取出3组患者少许椎体样本,椎体样本大小相等,不影响手术疗效的同时亦不会对患者造成不良影响,患者均表示知情同意。随后分别对取出的椎体标本进行显微计算机断层扫描术(micro-computed tomography,Micro-CT)检测,以了解及对比3组患者之间椎体骨密度(bone mineral density,BMD)、骨矿含量(bone mineral content,BMC)和骨小梁情况。结果骨质疏松性椎体压缩骨折患者组对比骨质疏松患者组、无骨质疏松患者组其椎体皮质骨BMD、松质骨BMD、骨小梁BMD和总体BMD以及皮质骨BMC、松质骨BMC和总BMC均有明显下降,差异具有统计学意义(P0.05),其中骨小梁BMD、皮质骨BMC、松质骨BMC和总BMC下降显著(P0.01);骨质疏松患者组对比无骨质疏松患者组其椎体皮质骨BMD、松质骨BMD、骨小梁BMD和总体BMD以及皮质骨BMC、松质骨BMC和总BMC均有下降,差异具有统计学意义(P0.05),其中骨小梁BMD下降显著(P0.01)。结论较低的椎体BMD和BMC是椎体压缩骨折发生发展的主要原因,骨质疏松患者和暂无骨质疏松人群需要预防BMD、BMC的下降,防止骨质疏松性椎体压缩骨折的发生。
[Abstract]:Objective to explore the difference of vertebral bone in patients with osteoporotic vertebral compression fracture, osteoporosis and non-osteoporosis. Methods Thirty patients who need surgical treatment were divided into two groups. There were 10 cases in each group of patients with osteoporotic vertebral compression fracture, group with osteoporosis and group without osteoporosis. A few vertebral body samples were taken out from 3 groups of patients during operation, and the size of vertebral samples was equal. There was no adverse effect on the outcome of the operation and no adverse effect on the patients. The patients gave their informed consent. The vertebral specimens were then examined by micro-computed tomography (micro-computed tomography micro-CT). To understand and compare the bone mineral density, bone mineral content and bone trabeculae between the three groups, results the patients with osteoporotic vertebral compression fracture were compared with the osteoporosis group. The cortical bone, cancellous bone, trabecular bone BMD and total BMD, cortical bone BMC, cancellous bone BMC and total BMC were significantly decreased in the group without osteoporosis. The difference was statistically significant (P 0.05), in which trabecular bone, cortical bone, cancellous bone BMC and total BMC decreased significantly (P 0.01), and the vertebral cortical bone, cancellous bone, bone trabecular BMD and total BMD in the osteoporosis group were compared with those in the non-osteoporosis group. Cortical bone BMC, cancellous bone BMC and total BMC were all decreased. The difference was statistically significant (P 0.05), among which the decrease of bone trabecular BMD was significant (P 0.01). Conclusion low BMD and BMC are the main causes of vertebral compression fracture, and the patients with osteoporosis and those without osteoporosis need to prevent the decline of BMD-BMC. Prevent osteoporotic vertebral compression fracture.
【作者单位】： 广州中医药大学;广州中医药大学中医骨伤科学国家重点学科实验室;广州中医药大学第一附属医院;
【基金】：广东省自然基金项目(2016A030313641) 广州中医药大学中医骨伤科学国家重点学科开放基金资助(YB12) 2016年国家级大学生创新创业训练计划项目(201610572262)
【分类号】：R687.3;R580
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