破骨细胞生物学特征的研究与进展

发布时间：2018-03-07 16:38

本文选题：破骨细胞　切入点：信号传导　出处：《中国组织工程研究》2017年11期 　论文类型：期刊论文

【摘要】：背景:骨组织处于不断塑建与重建的动态过程。成骨细胞生成骨质与破骨细胞吸收骨质的过程相互影响,共同维持着骨组织的动态平衡。破骨细胞作为骨组织中具有骨质吸收功能的细胞,其独特的功能吸引了众多学者对其进行研究。近几年,随着基因敲除技术、生物分子技术等技术的飞速发展,对破骨细胞的研究逐渐深入。目的:对最近破骨细胞形成、分化、功能不同分子机制及其调控因子的相关研究进行综述。方法:由第一作者检索1980至2015年Pub Med数据库中与破骨细胞形成、分化、功能的不同分子机制及调控因子研究相关的文献,以"osteoclast,molecular regulation,bone resorption,regulation mechanisms"为检索词,并进行系统整理、总结和分析。结果与结论:(1)共检索到文献151篇,按照纳入和排除标准进行筛选,最终共纳入英文文献29篇;(2)通过对文献认真阅读及分析,结果表明,RANK/RANKL/OPG轴对于骨质的形成和吸收过程具有关键的调节意义,研究破骨细胞信号通路及相关分子机制对骨关节疾病、成骨过程、骨免疫学、生物材料等方面的探索均有十分重要的影响。
[Abstract]:Background: bone tissue is in a dynamic process of remodeling and reconstruction. The process of osteogenesis and osteoclast absorption of osteoblasts interact with each other. The unique function of osteoclasts as bone resorption cells has attracted many scholars to study them. In recent years, with gene knockout technology, With the rapid development of biomolecules and other technologies, the study of osteoclasts has been gradually deepened. Objective: to investigate the formation and differentiation of osteoclasts. Methods: from 1980 to 2015, Pub Med database was used to search for different molecular mechanisms and regulatory factors related to osteoclast formation, differentiation and function. Taking "osteoclastositationbone resorption-regulation mechanisms" as the key word, and systematically sorting out, summarizing and analyzing, a total of 151 articles were retrieved and screened according to the inclusion and exclusion criteria. The results show that RANKR / RANKL / OPG axis plays a key role in the process of bone formation and absorption. Osteogenesis, bone immunology, biomaterials and other aspects of exploration have a very important impact.
【作者单位】：四川大学华西口腔医院正畸科国家口腔疾病重点实验室;
【基金】：国家自然科学基金(81371172)~~
【分类号】：R68

【相似文献】