帕洛诺司琼对比托烷司琼预防术后恶心呕吐有效性的Meta分析

发布时间：2018-03-09 07:46

本文选题：帕洛诺司琼　切入点：托烷司琼　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本研究目的在于通过Meta分析系统比较两种同类型的5-HT3受体拮抗剂帕洛诺司琼和托烷司琼在预防术后恶心呕吐的有效性方面是否存在差异。方法:根据PRISMA声明,本研究检索中文数据库包含:一、维普中文期刊数据库,二、相关期刊论文,三、万方数据库。检索的英文数据库包含有:一、Cochrane library,二、Embase,三、Pub Med数据库。检索时间从2006年1月至2016年9月。依据Cochrane Reviewer’s Handbook评估文献质量,应用软件Review Manager5.3分析文献的数据。结果:本研究总共收入15篇临床随机对照研究,Meta分析结果显示,帕洛诺司琼预防术后恶心呕吐发生的效果比托烷司琼更好【RR=0.62,95%CI(0.48,0.80),P0.001】,但帕洛诺司琼与托烷司琼在单独预防术后恶心或术后呕吐发生的效果差异无统计学意义【RR=0.74,95%CI(0.43,1.25),P=0.27】【RR=0.58,95%CI(0.29,1.15),P=0.10】。结论:帕洛诺司琼预防术后恶心呕吐比托烷司琼更有效。
[Abstract]:Objective: to compare the efficacy of paronosetron and tropisetron in the prevention of postoperative nausea and vomiting by Meta analysis system. Methods: according to the PRISMA statement, The main contents of this study are as follows: first, the Chinese journal database, the second, the full text database of the Chinese periodical, the third, the full text database of the Chinese periodical. Wanfang Database. The English databases are as follows: 1 Cochrane library, 2 Embase, 3 Pub Med. The retrieval time is from January 2006 to September 2016. The quality of literature is evaluated according to Cochrane Reviewer's Handbook. Results: a total of 15 clinical randomized controlled trials were included in this study. The effect of paronosetron on the prevention of postoperative nausea and vomiting was better than that of tropisetron [RRR0.6295CI0.480.80 P0.001], but there was no significant difference between paronosetron and tropisetron alone in the prevention of postoperative nausea or postoperative vomiting [RR0.7495CI0.431.25P0.27] [RRN 0.5895 CI0.291.15 P0.10]. Noisetron is more effective than tropisetron in preventing postoperative nausea and vomiting.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R614

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