重庆市三甲医院住院老年人肌肉减少患病率调查及其危险因素的分析

发布时间：2018-03-09 22:13

本文选题：肌肉减少症　切入点：住院老年人　出处：《重庆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：在本研究中,我们使用两种不同肌肉减少症(Sarcopenia)工作组推荐的诊断切割点来评估住院老年人肌肉减少的患病率,并分析了肌肉减少与一些潜在危险因素的相关性。方法：本研究纳入了重庆医科大学附属第一医院接受过DXA检查的694名住院老年人(男324、女370)。EWGSOP推荐使用肌肉指数,即使用DXA测量出四肢肌肉量再除以身高的平方作为判定有无肌肉减少的指标,其推荐的切割点男性为7.23-7.26kg/m2,女性为5.5-5.67kg/m2。2014年,AWGS发布了针对亚洲人群的肌肉减少筛查切割点,使用DXA测算出肌肉指数,如男性小于7.0 kg/m2或女性小于5.4 kg/m2则为肌肉减少。我们分别使用两个工作组推荐的切割点得出本研究人群肌肉减少的患病率,并且分析了骨骼肌减少与其他临床指标的关系。结果：用亚洲肌少症工作组的分割点时,男性肌肉减少患病率为45.9%,女性为36.7%；而参考欧洲老年人肌少症工作组的切割点时,男性肌肉减少患病率为56.6%,女性为28.6%。分别用两种切割点作诊断标准时,男性肌肉减少患病率之间存在着统计学差异,而女性则否。使用多元线性回归得出男性肌肉指数与全身肌肉指数(全身肌肉量／身高的平方)、BMI、腹部／臀部脂肪比值、TSH、HDL,而与估计的内脏脂肪质量、全身脂肪百分百、HbAlc和Hs-CRP呈负相关；女性肌肉指数与全身肌肉指数、BMI、髋关节骨密度T值、淋巴细胞计数、血浆前白蛋白、HDL呈正相关,而与全身骨密度Z值、全身脂肪百分百、空腹血糖呈负相关。结论：中国老年人人群肌肉减少患病率较高,高的体重和低的代谢水平是肌少症的保护因素,而肥胖、高血糖或糖尿病、营养不良和高水平的炎症应激是肌少症的危险因素。
[Abstract]:Objective: in this study, we used two different types of sarcopenia recommended by the working group to assess the prevalence of myopenia in the elderly in hospital. Methods: this study included 694 elderly patients (male 324, female 370, female 370) who underwent DXA examination in the first affiliated Hospital of Chongqing Medical University. EWGSOP recommended the use of muscle index. Even if the DXA was used to measure the muscle mass of the limbs divided by the square of height as an indicator of muscle loss, the recommended cutting point for men was 7.23-7.26 kg / m2, and for women 5.5-5.67 kg / m2. 2014 AWGS released a screening cut point for muscle reduction in Asian populations. Using DXA to measure muscle index, if male is less than 7. 0 kg/m2 or female is less than 5. 4 kg/m2, we use cutting point recommended by two working groups to estimate the prevalence of muscle loss in this study population. The relationship between skeletal muscle reduction and other clinical indicators was also analyzed. Results: the prevalence of muscle reduction was 45.9 in males and 36.7 in females when the Asian oligocytopathic group was used as the division point, while referring to the cutting point of the European working group on oligocythemia in the elderly, the incidence of muscle reduction was 45.9 in males and 36.7 in females. The prevalence of muscle reduction was 56.6 in male and 28.6in female. There was statistical difference between male and female when using two cutting points as diagnostic criteria. But not in women. The multiple linear regression analysis showed that the male muscle index and body muscle index (BMI), abdominal / hip fat ratio (TSHHDL), and visceral fat mass (visceral fat mass) were estimated. There was a negative correlation between 100% HbAlc and Hs-CRP in whole body fat, positive correlation between female muscle index and BMI, T value of hip bone mineral density, lymphocyte count, plasma prealbumin HDL, but positive correlation with Z value of BMD and 100% of whole body fat. Conclusion: high body weight and low metabolic level are the protective factors of hypomyopathy, while obesity, hyperglycemia or diabetes mellitus. Malnutrition and high levels of inflammatory stress are risk factors for hypomyopathy.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R685

【相似文献】