血清白蛋白水平变化与颅脑损伤程度的相关性分析

发布时间：2018-03-12 14:47

本文选题：颅脑损伤　切入点：血清白蛋白　出处：《内科急危重症杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的:探讨颅脑外伤患者的血清白蛋白水平变化与脑损伤程度的相关性,为辅助诊断急性颅脑损伤提供参考,减少迟发性脑损伤的发生率。方法:选取159例急性颅脑外伤患者,依据Glasgow评分,分为轻型组、中型组和重型组(各53例)。同时,选取在我院治疗的癫痫患者53例作为对照组。4组在入院第2、7、14天清晨空腹采静脉血,检测血清白蛋白、丙氨酸转氨酶(ALT)水平。结果:急性颅脑损伤程度越重,血清白蛋白水平下降越明显,ALT水平上升越明显。急性颅脑损伤程度与血清白蛋白水平呈负相关(r=-0.556,P=0.003),与ALT呈正相关(r=0.432,P=0.000)。不同时间点的血清白蛋白水平具有显著差异(P0.05);与对照组比较,轻型组的血清白蛋白水平变化无统计学意义(P0.05),中型组、重型组血清白蛋白水平变化有统计学意义(均P0.05)。不同时间点的血清ALT水平具有显著差异(均P0.05);时间变化和颅脑损伤之间存在交互效应(均P0.05)。结论:血清白蛋白水平变化与颅脑损伤程度呈负相关,血清白蛋白水平变化越大,患者颅脑损伤程度越重。
[Abstract]:Objective: to investigate the relationship between the changes of serum albumin level and the degree of brain injury in patients with craniocerebral trauma, to provide reference for the diagnosis of acute brain injury and to reduce the incidence of delayed brain injury. Methods: 159 patients with acute brain injury were selected. According to Glasgow score, they were divided into light group, medium group and severe group (53 cases each). At the same time, 53 epileptic patients treated in our hospital were selected as control group. Alanine aminotransferase (alt) level. Results: the more severe the acute craniocerebral injury, The lower the serum albumin level was, the more obvious the alt level was. There was a negative correlation between acute craniocerebral injury and serum albumin level, and a positive correlation with ALT. There was significant difference in serum albumin level at different time points (P 0.05). The level of serum albumin in mild group had no statistical significance (P 0.05). The changes of serum albumin level in severe group were statistically significant (all P 0.05). There were significant differences in serum ALT levels at different time points (all P 0.05), and there was an interactive effect between time changes and craniocerebral injury (all P 0.05). Conclusion: serum albumin in water has a significant effect on brain injury. The level change was negatively correlated with the degree of craniocerebral injury. The greater the change of serum albumin level, the more severe the patients with craniocerebral injury.
【作者单位】：西安市第一医院;
【分类号】：R651.15

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