改良的胃旁路术对GK大鼠非肥胖2型糖尿病的糖代谢影响研究

发布时间：2018-03-16 02:21

本文选题：改良的胃旁路术　切入点：Roux-en-Y胃旁路术　出处：《重庆医学》2017年33期 　论文类型：期刊论文

【摘要】：目的验证改良的胃旁路术治疗GK大鼠非肥胖2型糖尿病的可行性和有效性。方法将40只雄性GK大鼠分为4组,每组10只。A组为改良的胃旁路组,B组为Roux-en-Y胃旁路组,C组为假手术组,D组为空白对照组。分别检测各组术前1周及术后1、2、4、8、12周空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹血清胰岛素(FINS)水平。结果术后1周A组、B组大鼠体质量较D组明显下降,术后4周开始恢复,相同时间点A组、B组大鼠体质量比较差异无统计学意义(P0.05)。术前1周各组大鼠FPG、FINS、HbA1c比较,差异无统计学意义(P0.05)。术后1周各组大鼠FPG、FINS比较,差异无统计学意义(P0.05);术后2、4、8、12周A组、B组大鼠FPG、FINS比较差异无统计学意义(P0.05),而A组与C组、D组比较差异有统计学意义(P0.05)。术后4周各组HbA1c比较差异无统计学意义(P0.05),术后12周A组、B组比较差异无统计学意义(P0.05),而A组与C组、D组比较差异有统计学意义(P0.05)。结论改良的胃旁路术对大鼠非肥胖2型糖尿病的糖代谢具有改善作用,与Roux-en-Y胃旁路术相似。
[Abstract]:Objective to verify the feasibility and effectiveness of modified gastric bypass in the treatment of non-obese type 2 diabetes mellitus in GK rats. Methods 40 male GK rats were divided into 4 groups. 10 rats in each group were treated with modified gastric bypass. Group B was Roux-en-Y gastric bypass group. Group C was sham-operated group and group D was blank control group. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1cT) and fasting serum pancreatic (pancreas) were measured 1 week before operation and 1 week after operation. Results 1 week after operation, the body mass of rats in group A and group B was significantly lower than that in group D. At the same time, there was no significant difference in body mass between group A and group B, but there was no significant difference between the two groups at 1 week before operation (P 0.05), but there was no significant difference between the two groups at 1 week before operation (P 0.05), and at the first week after operation, there was no significant difference between the two groups in terms of the body mass of the rats in group A and group B, and the difference was not significant at the first week after operation. There was no significant difference (P 0.05) between group A and group C (P 0.05), but there was no significant difference between group A and group C (P 0.05) at 12 weeks after operation. There was no significant difference in HbA1c between group A and group C 4 weeks after operation (P 0.05), and there was no significant difference in HbA1c between group A and group C (P 0.05) at 4 weeks after operation, there was no significant difference in HbA1c between group A and group C (P 0.05), and there was no significant difference between group A and group C (P 0.05). At 12 weeks, there was no significant difference between group A and group B (P 0.05), but there was a significant difference between group A and group C (P 0.05). Conclusion improved gastric bypass surgery can improve the glucose metabolism of non-obese type 2 diabetes mellitus in rats. Similar to Roux-en-Y gastric bypass.
【作者单位】：广东药学院附属第二医院/广州新海医院普外科;
【基金】：广东省医学科学技术研究基金资助项目(A2015217)
【分类号】：R587.1;R656.6

【相似文献】