周围神经损伤后的神经再生和种植体周围神经再生的影响因素

发布时间：2018-03-19 02:24

本文选题：种植体表面　切入点：改性　出处：《国际口腔医学杂志》2016年01期 　论文类型：期刊论文

【摘要】：损伤的周围神经远侧端发生华勒变性,神经膜细胞去分化且大量增殖,吞噬损伤末端的轴突碎片,其分泌因子募集吞噬细胞到达损伤部位,共同清除崩解的髓鞘碎片。由此,神经膜细胞引导轴突再生,包裹轴突,形成髓鞘。在种植术后创口愈合的早期,种植体周围存在的神经丝蛋白染色阳性的纤维和之后再生的神经纤维成为种植义齿患者口腔感觉应答的基础。不同的钛表面微米级结构有利于神经细胞的吸附和增殖以及营养因子的分泌。神经生长因子为交感神经元和感觉神经元生长和存活所必需,肝素共轭纤维蛋白凝胶种植体和羟磷灰石-神经生长因子(NGF)复合涂层钛种植体均可缓慢释放具有活性的NGF,进而促进神经细胞的增殖及神经早期再生,改善种植体骨感知能力。种植体表面的微结构和化学成分是如何促进周围神经再生,其具体分子机制还不清楚,有待进一步研究。
[Abstract]:The distal end of the injured peripheral nerve dedifferentiated and proliferated in large numbers, and the axon fragments at the injured end were swallowed. The secreting factor of the phagocytes reached the injured site and together removed the broken myelin shards. The membrane cells guide axon regeneration, wrap the axon, and form myelin sheath. At the early stage of wound healing after implantation, The neurofilament staining positive fibers around the implant and the regenerated nerve fibers become the basis of oral sensory response in implant denture patients. Different microstructures on titanium surface are beneficial to the absorption of nerve cells. Proliferation and the secretion of nutrients. Nerve growth factors are necessary for the growth and survival of sympathetic and sensory neurons. Heparin conjugated fibrin gel implants and hydroxyapatite-NGF coated titanium implants could release active NGF slowly, thus promoting nerve cell proliferation and early nerve regeneration. How the microstructures and chemical components of implant surface promote peripheral nerve regeneration is unclear and the molecular mechanism remains to be further studied.
【作者单位】：吉林大学口腔医院种植科;
【基金】：吉林省卫生和计划生育科研课题(20142074)~~
【分类号】：R651.3

【相似文献】