术后认知功能障碍炎症相关机制及其防治

发布时间：2018-03-20 21:37

  本文选题：术后认知功能障碍　切入点：手术　出处：《中南大学学报(医学版)》2017年11期 　论文类型：期刊论文

【摘要】：术后认知功能障碍(postoperative cognitive dysfunction,POCD)是一种轻度的认知功能紊乱,是指术前无认知障碍的患者在麻醉手术后出现精神活动、人格、社交活动及认知能力的改变。记忆减退是认知功能障碍患者的核心症状及表现,年龄是术后长期认知功能损害的主要危险因素。POCD的发生将延长患者的住院时间,降低患者的生存质量,增加术后死亡率,给个人和社会造成严重负担。如何有效地预防、干预POCD的发生发展,减少不良后果,是手术患者(尤其是老年患者)围手术期亟需解决的问题。虽然POCD的病理生理机制仍然不明,但目前倾向于认为炎症在POCD中扮演重要作用。无菌手术诱导外周炎症反应,通过相关途径传入中枢,因个体差异,导致了不同严重程度的中枢炎症反应,进而引起POCD。因此,针对POCD的防治方法也应着重围绕减轻炎症反应展开。
[Abstract]:Postoperative cognitive dysfunctional POCDD is a mild cognitive disorder, which refers to the mental activity and personality of patients without cognitive impairment before anesthesia. Memory impairment is the core symptom and manifestation of cognitive dysfunction. Age is the main risk factor of long-term cognitive impairment. POCD will prolong the hospitalization time of the patients. How to effectively prevent and intervene in the occurrence and development of POCD, and reduce the adverse consequences, reduce the quality of life of patients, increase the postoperative mortality, and cause a serious burden to individuals and society. Although the pathophysiological mechanism of POCD is still unknown, it tends to think that inflammation plays an important role in POCD. Because of the individual difference, the central inflammatory reaction of different severity is caused by the relevant pathway. Therefore, the prevention and treatment of POCD should focus on alleviating the inflammatory reaction.
【作者单位】： 中南大学湘雅三医院麻醉科;
【基金】：国家自然科学基金(81371216)~~
【分类号】：R614
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本文编号：1640887