乳清蛋白和复合维生素对老年肌肉衰减综合征的干预效果研究

发布时间：2018-03-22 04:30

本文选题：老年人　切入点：肌肉衰减综合征　出处：《郑州大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的探索补充维生素D、维生素E和乳清蛋白对肌肉衰减综合征老年人肌肉质量、功能和强度的影响。方法于2015年10月至2016年1月期间,选取郑州市上街区具有良好沟通能力,无已知身体或精神疾病的60岁及以上老年人进行肌肉衰减综合征筛查。共60名肌肉衰减综合征患者纳入本研究。采用计算机生成的随机数字,以性别、年龄做匹配,将研究对象分为干预组和安慰剂组,每组30人,干预组给予乳清蛋白联合制剂,每日两次,每次20g。安慰剂组给予等能量、等重量安慰剂,其服用方法与干预组相同。干预6个月,期间受试者保持平时的生活和饮食习惯,每一个月随访一次。在干预开始前和干预结束后分别测量研究对象的相对骨骼肌质量指数,握力,6-m步行时间,起立走计时,椅上坐站试验,营养状况,生活质量,血清学指标。采用频数(构成比)、均数±标准差对基线资料进行描述性统计。采用协方差分析比较两组干预前后相对骨骼肌质量指数和握力变化是否存在差异;采用独立样本t检验比较干预前后两组6-m步行时间,起立走计时,椅上坐站试验,四肢骨骼肌含量,生活质量和血清生化指标变化是否有差异。结果结果显示干预组四肢骨骼肌含量变化值为0.23±1.07 kg,安慰剂组变化值为-0.25±0.71 kg,差异具有统计学意义(P=0.043)。干预组握力变化值为1.9±4.24kg,安慰剂组变化值为-0.88±3.20 kg,差异有统计学意义(P=0.006);干预组相对骨骼肌质量指数变化值为0.08±0.38 kg/m2,安慰剂组变化值为-0.13±0.31kg/m2,差异具有统计学意义(P=0.021);干预组6-m步行时间变化值为-1.01±1.50 s,安慰剂组变化值为-0.02±5.17 s,差异无统计学意义(P=0.312)。干预后干预组血清甘油三脂变化值为-0.23±0.52 mmol/L,安慰剂组变化值为0.01±0.41 mmol/L,差异有统计学意义(P=0.046);干预组胰岛素样生长因子-1变化值为14.18±28.33ng/m L,安慰剂组变化值为-1.13±17.96 ng/m L,差异具有统计学意义(P=0.015);干预组白介素-2变化值为40.17±487.18 pg/m L,安慰剂组变化值为633.3±1362.27 pg/m L,差异具有统计学意义(P=0.029)。干预后干预组生活质量明显改善,干预躯体维度综合变化值为17.39±16.92,安慰剂组变化值为-2.28±17.01,差异有统计学意义(P0.001);干预组心理维度综合变化值为12.98±13.70,安慰剂组变化值为2.20±14.23,差异具有统计学意义(P=0.004)。结论(1)联合补充乳清蛋白、维生素D和E可以改善肌肉衰减综合征患者肌肉质量和力量。(2)联合补充乳清蛋白、维生素D和E可以改善肌肉衰减综合征患者生活质量。(3)联合补充乳清蛋白、维生素D和E可以改善肌肉衰减综合征患者血清甘油三脂、胰岛素样生长因子-1、白介素-2水平。
[Abstract]:Objective to explore the effects of vitamin D, vitamin E and whey protein supplementation on muscle quality, function and strength in elderly patients with muscular attenuation syndrome. A total of 60 patients with muscular attenuating syndrome were enrolled in this study. A total of 60 patients with muscular attenuation syndrome were enrolled in the study. Random numbers were generated by computer and matched by sex and age. Participants were divided into intervention group and placebo group, 30 people in each group. The intervention group was given whey protein combined preparation twice a day, 20g. placebo group was given equal energy and equal weight placebo. The method was the same as that in the intervention group. After 6 months of intervention, the subjects maintained their normal living and eating habits, followed up once a month. The relative skeletal muscle mass index of the subjects was measured before and after the intervention. Grip strength 6-m walking time, standing time, chair sitting test, nutritional status, quality of life, The baseline data were analyzed by frequency (composition ratio, mean 卤standard deviation). Covariance analysis was used to compare whether there were differences in relative skeletal muscle mass index and grip strength between the two groups before and after intervention. T test was used to compare 6-m walking time, standing time, chair sitting test and skeletal muscle content in the two groups before and after intervention. The results showed that the change value of skeletal muscle content in the intervention group was 0.23 卤1.07 kg, the change value in the placebo group was -0.25 卤0.71 kg, the difference was statistically significant. The change value of grip strength in the intervention group was 0.23 卤1.07 kg and that in the placebo group was -0.25 卤0.71 kg, respectively. 1.9 卤4.24 kg, -0.88 卤3.20 kg in placebo group, 0.08 卤0.38 kg / m2 in intervention group and -0.13 卤0.31 kg / m ~ (2) in placebo group, and 6-m walking time in intervention group were -1.01 卤1.50 kg / m ~ (-2), respectively, the difference was statistically significant (P < 0.05), and that of intervention group was -1.01 卤1.50 kg 路m ~ (-2), that of placebo group was -0.13 卤0.31 kg / m ~ (-2), and that of intervention group was -1.01 卤1.50 kg 路m ~ (-2). After intervention, the change of serum triglyceride was -0.23 卤0.52 mmol / L, and that of placebo group was 0.01 卤0.41 mmol / L, the difference was statistically significant (P0.046), while that of intervention group was -0.23 卤0.52 mmol / L (P < 0.05), and that of placebo group was 0.01 卤0.41 mmol / L (P < 0.05). The value of interleukin-2 in the intervention group was 40.17 卤487.18 pg/m / L, and the value in the placebo group was 633.3 卤1362.27 pg/m / L, the difference was statistically significant (P0.0299.The quality of life in the intervention group was significantly improved after the intervention, and the change value of the placebo group was -1.13 卤17.96 ng/m / L, P < 0.05), the difference was statistically significant (P < 0.05), and that of the intervention group was 40.17 卤487.18 pg/m / L and 633.3 卤1362.27 pg/m / L, respectively. The comprehensive change value of somatic dimension in intervention group was 17.39 卤16.92, that in placebo group was -2.28 卤17.01, the difference was statistically significant (P 0.001), the psychological dimension of intervention group was 12.98 卤13.70, the change value of placebo group was 2.20 卤14.23, the difference was statistically significant (P0.0044.Conclusion 1). Vitamin D and E can improve muscle mass and muscle strength in patients with muscular attenuation syndrome, and supplement whey protein. Vitamin D and E can improve quality of life in patients with muscular attenuation syndrome. Vitamin D and E can improve serum triglyceride, insulin-like growth factor-1 and interleukin-2 levels in patients with muscular attenuation syndrome.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R685

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