电针督脉经穴联合成体干细胞移植策略在修复脊髓损伤中的研究进展

发布时间：2018-03-23 22:11

本文选题：电针　切入点：督脉经穴　出处：《中山大学学报(医学科学版)》2017年06期

【摘要】：本文以电针督脉经穴、内源性神经营养因子表达、移植的成体干细胞源性神经元与脊髓宿主神经元环路整合修复脊髓损伤为主线,概述了电针督脉经穴联合成体干细胞移植改善脊髓损伤组织微环境重建神经元传导通路机制—电针督脉经穴刺激全横断脊髓损伤或脊髓脱髓鞘损伤的大鼠脊膜支传入神经纤维将信息传入脊髓,激活脊髓组织细胞合成和分泌神经营养素-3(NT-3),介导表达NT-3受体Trk C的外源性神经干细胞(NSC)和骨髓间充质干细胞(MSC)在全横断脊髓损伤/移植处或脊髓脱髓鞘损伤/移植处存活、分化和迁移,替换和保护受损伤的宿主神经元、改善受损伤组织微环境、促进神经纤维再生及其髓鞘形成、改善大脑皮层运动诱发电位以及瘫痪肢体的运动功能。
[Abstract]:In this paper, electroacupuncture Du meridian, the expression of endogenous neurotrophic factor, transplantation of adult stem cells derived neurons and spinal cord neurons host loop repair of spinal cord injury integration as the main line, the stem cell transplantation improves spinal cord injury tissue microenvironment in spinal neuron pathway reconstruction mechanism of electroacupuncture Du Meridian stimulation of the transected spinal cord injury or spinal cord demyelinating injury in rats with afferent nerve fiber transmits into spinal cord combined with electroacupuncture Du meridian, activation of spinal cord cells synthesis and secretion of neurotrophins (-3, NT-3) mediated by exogenous expression of NT-3 receptor Trk C neural stem cells (NSC) and bone marrow mesenchymal stem cells (MSC) survival in transection spinal cord injury / transplantation or demyelinated spinal cord injury / transplantation, differentiation and migration, replace and protect injured host neurons, improve the microenvironment of damaged tissue, promote nerve fiber Vascular regeneration and its myelin formation can improve the motor evoked potential of the cerebral cortex and the motor function of paralyzed limbs.

【作者单位】：中山大学中山医学院组织胚胎学教研室;中山大学中山医学院广东省脑功能与脑疾病重点实验室;中山大学脊髓损伤研究所;
【基金】：国家自然科学基金面上项目(30472132;30973721;8167150879;81774397)
【分类号】：R651.2

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