盐酸戊乙奎醚复合乌司他丁对行开胸术患者术后认知功能的影响及机制研究

发布时间：2018-04-04 15:49

  本文选题：盐酸戊乙奎醚　切入点：乌司他丁　出处：《重庆医学》2017年12期

【摘要】：目的探讨盐酸戊乙奎醚复合乌司他丁对行开胸术患者术后认知功能的影响。方法将120例行开胸肺癌根治术患者分为盐酸戊乙奎醚复合乌司他丁组(HU组)、盐酸戊乙奎醚组(H组)、乌司他丁组(U组)和对照组(C组)。采集动脉血检测氧合指数(OI)、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6和IL-8,检测血清中S-100β和神经元特异性烯醇化酶(NSE)水平,评估简易精神状态评价量表(MMSE)评分。结果与H组和U组相比,HU组T3~4时TNF-α均降低,T2~4时IL-6和IL-8均降低,而OI升高(P0.05);与H组和U组相比,HU组患者T5~8时血清S-100β和NSE水平均降低(P0.05);与H组和U组相比,HU组患者T6~7时MMSE评分升高(P0.05)。结论盐酸戊乙奎醚复合乌司他丁可减轻开胸术单肺通气时炎症反应,改善术后认知功能。
[Abstract]:Objective to investigate the effect of pentehyclidine hydrochloride combined with ulinastatin on cognitive function of patients undergoing thoracotomy.Methods 120 patients with open chest lung cancer were divided into three groups: penehyclidine hydrochloride combined with ulinastatin group (Hu group), penehyclidine hydrochloride group (group H), ulinastatin group (group U) and control group (group C).Arterial blood samples were collected to detect the oxygenation index (OIN), tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6) and interleukin-8 (IL-8). The levels of S-100 尾 and neuron-specific enolase (NSEs) were measured to evaluate the MMSE score.缁撴灉涓嶩缁勫拰U缁勭浉姣，

本文编号：1710635