两种静脉麻醉药物配伍的安全窗比较

发布时间：2018-04-06 03:11

本文选题：地佐辛　切入点：芬太尼　出处：《重庆医学》2017年07期

【摘要】：目的比较地佐辛与芬太尼分别复合丙泊酚行静脉全身麻醉(全麻)时的安全窗。方法选择拟在静脉全身麻醉下行无痛宫腔镜手术的患者80例,采用随机数字表法将患者分为丙泊酚复合芬太尼组(PF组)、丙泊酚复合地佐辛组(PD组),每组40例。测定每组抑制体动及抑制呼吸的半数有效浓度(EC50),同组内两EC50间的差值视为安全窗,统计比较两组安全窗的宽度,并记录患者术前基础(T0)、血药浓度达稳定(T1)、切皮(T2)、切皮后5 min(T3)、术毕拔管(T4)时的平均动脉压(MAP)、心率(HR)。结果 PD组安全窗宽度明显高于PF组(P0.05)。PD组T1~3时刻的MAP及HR明显高于PF组(P0.05)。结论地佐辛复合丙泊酚行静脉全身麻醉时,在抑制呼吸和体动反应间的安全窗更宽,安全性优于芬太尼。
[Abstract]:Objective to compare the safety windows of dizosin and fentanyl combined with propofol during intravenous general anesthesia.Methods Eighty patients undergoing painless hysteroscopy under intravenous general anesthesia were randomly divided into propofol combined with fentanyl group (PF group) and propofol combined with dizosin group (PD group) with 40 cases in each group.EC50 was measured in each group. The difference between the two EC50 in the same group was regarded as a safe window, and the width of the safe window was statistically compared between the two groups.The mean arterial pressure (MAPP) and heart rate (HRT) were recorded in patients with T0, T1, T2, T3, T4 after extubation.Results the width of safe window in PD group was significantly higher than that in PF group (P 0.05). The MAP and HR of PD group were significantly higher than that of PF group (P 0.05).Conclusion the safety window of dizosin combined with propofol is wider than that of fentanyl during general intravenous anesthesia.
【作者单位】：南方医科大学附属小榄人民医院麻醉科;
【基金】：广东省中山市科技计划项目(2014A1FC117)
【分类号】：R614.24

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