盐酸右美托咪定对脓毒症患者围手术期血清细胞因子及高迁移率族蛋白B1的影响

发布时间：2018-04-09 12:20

本文选题：脓毒症　切入点：盐酸右美托咪定　出处：《中华医院感染学杂志》2017年03期

【摘要】：目的探讨盐酸右美托咪定对脓毒症患者围手术期血清白细胞介素-10(Interleukin-10,IL-10)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)及高迁移率族蛋白B1(High mobility group protein B1,HMGB1)的影响。方法选择医院2014年1月-2015年12月需手术治疗的脓毒症患者94例为研究对象,将其分为右美托咪定组和对照组,每组各47例,右美托咪定组患者麻醉过程中静脉泵入盐酸右美托咪定,对照组静脉泵入等量生理盐水,采用ELISA法测定血清IL-10、IL-6、TNF-α和HMGB1水平。结果两组患者手术结束时和术后24h血清IL-10水平均高于麻醉诱导前和手术1h(P0.05);与对照组比较,右美托咪定组手术结束时和术后24h血清IL-10水平明显高于对照组(P0.05);两组患者手术结束时和术后24h血清IL-6、TNF-α和HMGB1水平均高于麻醉诱导前和手术1h(P0.05);与对照组比较,右美托咪定组手术结束时和术后24h血清IL-6、TNF-α和HMGB1水平明显低于对照组(P0.05)。结论脓毒症患者围手术期血清IL-10、IL-6、TNF-α和HMGB1水平均升高,右美托咪定可以降低血清IL-6、TNF-α和HMGB1水平,升高血清IL-10。
[Abstract]:Objective to investigate dexmedetomidine hydrochloride on perioperative serum IL-2 in patients with sepsis in -10 (Interleukin-10, IL-10), interleukin -6 (Interleukin-6, IL-6), tumor necrosis factor alpha (Tumor alpha factor- alpha necrosis, TNF-) and high mobility group protein B1 (High mobility group protein B1, HMGB1). The influence of selection method of hospital in January 2014 -2015 year in December the need for surgical treatment of the patients with sepsis and 94 cases as the research object, which can be divided into dexmedetomidine group and control group, 47 cases in each group, dexmedetomidine during intravenous infusion of dexmedetomidine hydrochloride group anesthesia control group, intravenous infusion of normal saline, serum IL-10 was determined by ELISA method, IL-6, TNF- alpha and HMGB1 level. Results in the end of two groups of patients with surgery and postoperative 24h serum level of IL-10 was higher than that before induction of anesthesia and surgery 1H (P0.05); compared with the control group, dexmedetomidine group At the end of 24h and postoperative serum IL-10 levels were significantly higher than the control group (P0.05); the end of the two groups of patients with operation time and postoperative serum 24h IL-6, TNF- alpha and HMGB1 was higher than before the induction of anesthesia and surgery 1H (P0.05); compared with the control group, dexmedetomidine group at the end of surgery and 24h after surgery serum IL-6, TNF- and HMGB1 levels were significantly lower than the control group (P0.05). Serum IL-10, perioperative sepsis patients conclusion during IL-6, TNF- and HMGB1 levels were elevated, dexmedetomidine can reduce the serum levels of IL-6, TNF- and HMGB1 levels, elevated serum IL-10.

【作者单位】：义乌市中心医院麻醉科;
【基金】：浙江省医药卫生一般研究计划基金资助项目(2014KYB297)
【分类号】：R614

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