水飞蓟宾胶囊对行肝切除术后患者肝脏保护作用的临床评价

发布时间：2018-04-16 18:06

  本文选题：水飞蓟宾胶囊 + 肝切除术　； 参考：《中国医院药学杂志》2017年10期

【摘要】：目的:研究水飞蓟宾对行肝切除术后患者的肝脏临床保护作用。方法:对某院行肝切除术的患者随机分为观察组和对照组,其中观察组患者于实验前一个星期给予水飞蓟宾胶囊,术后静脉滴注还原型谷胱甘肽和异甘草酸镁注射液治疗,对照组患者仅于术后静脉滴注还原型谷胱甘肽和异甘草酸镁注射液治疗,术后7 d内观察记录患者的肝衰竭和肝功能不足发生情况,于术前及术后1,3,5 d和7 d,测定患者血清中总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)和谷草转氨酶(AST)水平,评估水飞蓟宾胶囊对术后患者肝脏保护作用。结果:观察组肝衰竭和肝功能不足发生率显著低于对照组(χ~2=6.202,P=0.0130.05;χ~2=4.579,P=0.0320.05);术后1 d,观察组的ALT水平为(287.5±115.8)U·L~(-1),AST水平为(215.7±121.4)U·L~(-1),TBIL水平为(23.3±9.7)μmol·L~(-1),DBIL水平为(8.6±5.1)μmol·L~(-1),对照组的ALT(387.5±156.9)U·L~(-1),AST水平为(316.8±176.4)U·L~(-1),TBIL水平为(27.4±10.3)μmol·L~(-1),DBIL水平为(13.2±5.3)μmol·L~(-1),2组相比,差异有统计学意义(P0.05)。术后7 d,观察组患者的ALT水平为(41.4±11.5)U·L~(-1),AST水平为(31.9±6.3)U·L~(-1),TBIL水平为(5.5±5.4)μmol·L~(-1),DBIL水平为(4.2±3.4)μmol·L~(-1),对照组患者的ALT水平为(114.7±35.2)U·L~(-1),AST水平为(98.5±13.7)U·L~(-1),TBIL水平为(14.3±5.8)μmol·L~(-1),DBIL水平为(7.2±3.5)μmol·L~(-1),2组相比,差异有统计学意义(P0.05)。结论:术前应用水飞蓟宾胶囊,可有效减轻手术对肝功能的影响;术后应用水飞蓟宾胶囊治疗,可以显著恢复患者肝功能。
[Abstract]:Objective: to study the clinical protective effect of silybin on liver after hepatectomy.Methods: patients undergoing hepatectomy in a certain hospital were randomly divided into observation group and control group. The patients in the observation group were given silybin capsule one week before the experiment and were treated by intravenous drip of glutathione and magnesium isoglycyrrhizinate injection after operation.The patients in the control group were treated with reduced glutathione and magnesium isoglycyrrhizinate only by intravenous drip. The incidence of liver failure and hepatic insufficiency were observed and recorded within 7 days after operation.The serum levels of Tbilirubin, direct bilirubin, alanine aminotransferase (alt) and aspartate aminotransferase (AST) were measured before and 1 day after operation. The protective effect of silylubin capsule on the liver of postoperative patients was evaluated.缁撴灉:瑙傚療缁勮倽琛扮��鍜岃倽鍔熻兘涓嶈冻鍙戠敓鐜囨樉钁椾綆浜庡�圭収缁�(蠂~2=6.202,P=0.0130.05;蠂~2=4.579,P=0.0320.05);鏈�鍚�1 d,瑙傚療缁勭殑ALT姘村钩涓，

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