骨性关节炎所致慢性持续性疼痛的发病机制

发布时间：2018-04-17 06:58

本文选题：骨性关节炎 + 慢性神经病理性疼痛　；参考：《中国骨质疏松杂志》2017年02期

【摘要】：在世界范围内,骨关节炎(osteoarthritis,OA)已成为引起肌肉骨骼疼痛和功能残疾的主要病因。尽管临床上已使用多种保守或介入治疗方法,但是仍不能有效控制OA所致的疼痛。各种原因引起的慢性疼痛特别是神经病理性疼痛是最具挑战的临床医疗和公众健康问题,给患者及其家庭乃至社会带来沉重的精神和经济负担。慢性疼痛治疗手段繁多但疗效却并不满意,究其原因主要是对慢性疼痛的发生发展机制认识尚不足,且已知的科研成果尚未转化为临床治疗手段。本文旨在综述OA所致慢性疼痛的潜在病理生理机制,以期探讨新的有效控制OA痛的作用靶点,对新药研发及新的治疗策略提供思路。
[Abstract]:Osteoarthritis (OAA) has become a major cause of musculoskeletal pain and functional disability worldwide.Although a variety of conservative or interventional therapies have been used clinically, pain caused by OA can not be effectively controlled.Chronic pain caused by various causes, especially neuropathic pain, is the most challenging clinical medical and public health problem, which brings a heavy mental and economic burden to patients, their families and even society.There are many treatment methods for chronic pain, but the curative effect is not satisfactory. The main reason is that the mechanism of the occurrence and development of chronic pain is not well understood, and the known scientific research results have not been transformed into clinical treatment methods.The purpose of this paper is to review the underlying pathophysiological mechanisms of chronic pain induced by OA in order to explore new targets for effective control of OA pain and to provide ideas for the development of new drugs and new therapeutic strategies.
【作者单位】：山东大学附属省立医院药剂科;山东大学附属省立医院乳腺甲状腺外科;
【基金】：国家自然科学基金资助项目(81300964) 中国博士后科学基金资助项目(2014T70648);中国博士后科学基金面上资助项目(2013M531611) 山东省中医药科技发展计划项目(2013-190)
【分类号】：R684.3

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