右美托咪定对全麻苏醒期患者躁动及围手术期医院感染的影响

发布时间：2018-04-17 16:04

本文选题：右美托咪定 + 全麻苏醒期　；参考：《中华医院感染学杂志》2017年23期

【摘要】：目的分析右美托咪定对全麻苏醒期患者躁动及围手术期医院感染的影响。方法选取2013年2月-2016年5月期间于医院接受治疗的120例脑膜瘤切除术患者,随机分为试验组与对照组,每组各60例;观察分析两组在术前与苏醒期的心率(HR)、收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)及脉搏血氧饱和度(SpO2)指标水平,视觉模拟评分法(VAS)评分,手术前后的肿瘤坏死因子-α(TNF-α)及白细胞介素-8(IL-8)水平及并发症情况。结果两组术前与苏醒期的HR、MAP、SpO2、SBP、DBP指标水平有差异(P0.05),且试验组苏醒期的HR、MAP、SpO2指标均高于对照组(P0.05);全麻苏醒期,试验组躁动发生率11.67%低于对照组的31.67%(P0.05);术后试验组的TNF-α、CRP与IL-8水平低于对照组(P0.05);术后,试验组患者总不良反应发生率率为8.33%,低于对照组的23.33%(P0.05)。结论右美托咪定可以降低全麻苏醒期患者的躁动率及改善脉搏指标水平,同时可以降低围手术期患者的医院感染率,并改善预后,有助于患者的身心健康。
[Abstract]:Objective to analyze the effect of dexmetomidine on restlessness and perioperative nosocomial infection in patients with general anesthesia.Methods from February 2013 to May 2016, 120 patients with meningioma were randomly divided into two groups: experimental group (n = 60) and control group (n = 60).The indexes of HR, SBP, DBP, MAPP, SPO _ 2 and visual analogue score were observed and analyzed in the two groups before and during the period of recovery, and the visual analogue score (VAS) was used to evaluate the mean arterial pressure and diastolic blood pressure (DBP), mean arterial pressure (MAPP), pulse oxygen saturation (SPO _ 2) and visual analogue score (VAS).The levels and complications of TNF- 伪 and IL-8 before and after operation.Results there was significant difference between the two groups in the DBP index levels of HRP MAPP spo _ 2 and SBP _ 2 in the two groups, and the indexes of HRP MAPO _ 2 SPO _ 2 in the trial group were higher than those in the control group (P 0.05), and in the period of general anesthesia, there was no significant difference between the two groups.The incidence of restlessness in the test group was 11.67% lower than that in the control group (31.67%), the level of TNF- 伪 -CRP and IL-8 in the experimental group was lower than that in the control group (P 0.05), and the incidence rate of total adverse reaction in the test group was 8.33%, which was lower than that in the control group (23.33%).Conclusion dexmetomidine can decrease the restlessness rate and improve the pulse index in patients with general anesthesia. It can also reduce the nosocomial infection rate and improve the prognosis of patients during perioperative period. It is beneficial to the physical and mental health of patients.
【作者单位】：玉环市人民医院麻醉科;温州医科大学附属第一医院麻醉科;
【基金】：浙江省自然科学基金资助项目(HY11H19002)
【分类号】：R614

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