七氟烷麻醉抑制急性创伤性颅脑损伤患者围手术期炎症介质的表达

发布时间：2018-04-17 17:05

  本文选题：创伤性颅脑损伤 + 七氟烷　； 参考：《中国免疫学杂志》2017年10期

【摘要】：目的:探讨七氟烷麻醉对急性创伤性颅脑损伤患者围手术期炎症介质表达、神经功能损害及患者预后的影响。方法:收集2015年7月至2016年12月急诊开颅手术的创伤性颅脑损伤患者80例,随机分为试验组(七氟烷处理组)和对照组,各40例。围手术期抽取外周血,利用酶联免疫吸附测定法检测血清中TNF-α、IL-6、CRP蛋白和NSE浓度,比较两组患者GCS评分、APACHEⅡ评分和预后。结果:与对照组比较,试验组在术中1 h、术毕和术后第1天血清炎症介质(CRP、TNF-α、IL-6)表达明显降低(P0.05或0.01),神经元特异性烯醇化酶NSE蛋白在术毕及术后第1天表达降低(P0.05或0.01);七氟烷处理有效改善患者病情,在第14天GCS评分[(10.82±1.40)比(8.29±1.02),P=0.03],APACHEⅡ评分[(14.42±1.97)比(18.03±2.15),P=0.02]。结论:七氟烷处理可通过抑制创伤性颅脑损伤患者围手术期伤后炎症反应,减少神经元细胞损害,起到神经保护作用和改善患者预后。
[Abstract]:Aim: to investigate the effect of sevoflurane anesthesia on the expression of inflammatory mediators, neurological impairment and prognosis in patients with acute traumatic brain injury.Methods: 80 patients with traumatic craniocerebral injury underwent emergency craniotomy from July 2015 to December 2016 were randomly divided into experimental group (sevoflurane treated group) and control group (40 cases each).Peripheral blood was drawn from perioperative period. Serum TNF- 伪 IL-6 CRP protein and NSE concentration were detected by enzyme linked immunosorbent assay (Elisa). The GCS score and Apache 鈪，

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