青年女性乳腺癌晚期患者78例术后生存情况分析

发布时间：2018-04-29 06:15

  本文选题：肿瘤 + 乳腺癌　； 参考：《广东医学》2016年21期

【摘要】：目的分析青年女性乳腺癌晚期患者术后生存情况,为青年乳腺癌患者临床治疗和预测其预后提供参考依据。方法应用Kaplan-Meier法、Log-rank检验和Cox多元回归模型分析入院治疗的78例20~45岁青年女性乳腺癌晚期患者年龄、TNM分期、病理类型、术后化疗方式与患者总体生存率的关系。结果 78例青年女性乳腺癌晚期患者1~5年总体生存率为84.28%、72.24%、65.36%、45.75%和45.75%。单因素分析结果表明,不同分组的总体生存率比较,TNMⅢ期患者高于Ⅳ期的晚期患者(X~2=15.123,P0.001);行化疗规范方案的患者组高于化疗不规则的患者(X~2=5.718,P=0.017);城区患者高于农村地区患者(X~2=6.568,P=0.010);T1+T2期的患者组高于T3+T4期患者(X~2=5.062,P=0.024);尚未发现青年女性乳腺癌晚期患者的总体生存率与病理类型、年龄、肿瘤部位有统计学关联(X~2=0.113、0.613、0.624,P=0.737、0.434、0.430);多因素Cox回归模型分析结果表明,除诊断TNM高分期外,经济不发达的农村地区(RR=3.146,95%CI=1.019~9.716,P=0.046)及不规则化疗(RR=3.591,95%CI=1.169~11.033 5,P=0.026)是青年女性乳腺癌晚期患者总体生存率降低的独立危险因素。结论术后规范化疗是青年女性乳腺癌晚期患者康复治疗的有效手段,有利于提高患者生存率。
[Abstract]:Objective to analyze the postoperative survival of young female patients with advanced breast cancer and to provide reference for the clinical treatment and prognosis of young women with breast cancer. Methods the relationship between age, pathological type, postoperative chemotherapy and overall survival rate of 78 female patients with advanced breast cancer aged 20 to 45 years were analyzed by Kaplan-Meier method and Cox multivariate regression model. Results the overall 1 ~ 5 year survival rate of 78 young female patients with advanced breast cancer was 84.28% and 72.24% respectively. The total survival rate was 45.75% and 45.75% respectively. The results of single factor analysis show that, The overall survival rate of TNM 鈪，

本文编号：1818744