脐带间充质干细胞联合神经导管治疗大鼠股神经缺损的研究

发布时间：2018-05-06 11:01

本文选题：干细胞 + 神经导管　；参考：《世界最新医学信息文摘》2016年50期

【摘要】：随着社会经济状况的改善,四肢创伤与周围神经损伤的发生率正逐日提高。周围神经损伤后有较强的再生能力;随着纤维外科器械的普及,神经损伤后缝合精确度已大大提高。但即使进行了早期精确的神经吻合仍无法达到神经功能的完全恢复,这在很大的程度上是因为近端神经再生的运动/感觉神经轴突错误地长入了远端感觉/运动神经通道内而使靶组织与器官失去了正确支配信号造成的。神经趋化的理论以及在此基础上建立起来的小间隙神经桥接法为神经损伤后准确对接提供了新的思路。本研究中,我们将首次联合应用神经导管、脐带Wharton胶间充质干细胞以及碱性成纤维细胞生长因子(b FGF)桥接大鼠股神经并比较其在不同的条件下再生修复的效果。研究结果不仅对以后的临床治疗有一定的指导意义,也能为神经趋化性再生理论的深入研究提供宝贵的实验依据。
[Abstract]:With the improvement of social and economic condition, the incidence of limb injury and peripheral nerve injury is increasing day by day. With the popularization of fiberoptic surgical instruments, the accuracy of nerve suture after nerve injury has been greatly improved. But even with an early and accurate neurorrhaphy, the complete recovery of nerve function can not be achieved. This is largely due to the fact that the motor / sensory nerve axons of the proximal nerve regenerate incorrectly into the distal sensory / motor nerve channel and the target tissues and organs lose the correct innervation signal. The theory of neural chemotaxis and the bridging method of small gap nerve provided a new idea for accurate docking after nerve injury. In this study, we will use nerve conduit, umbilical cord Wharton mesenchymal stem cells and basic fibroblast growth factor (bFGF) for the first time to bridge rat femoral nerve and compare the effect of regeneration and repair under different conditions. The results not only have certain guiding significance for clinical treatment in the future, but also provide valuable experimental basis for the further study of the theory of chemotaxis regeneration.
【作者单位】：贵州省安顺市中国贵航集团三零二医院;
【分类号】：R651.3

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