眼镜蛇伤患者血清分泌型磷脂酶A2变化及临床意义

发布时间：2018-05-10 11:17

  本文选题：分泌型磷脂酶A2 + 眼镜蛇咬伤　； 参考：《南华大学》2016年硕士论文

【摘要】：目的:分析眼镜蛇咬伤患者血清sPLA2变化,探讨其与眼镜蛇伤患者病情严重程度的关系及意义。方法:南华大学附属南华医院蛇伤中毒科住院和留观病区2015年1月~2015年12月间,按纳入标准和排除标准收治的眼镜蛇咬伤患者52例。按就诊时病情程度分为:轻型及重危型组。眼镜蛇咬伤后患肢的肿胀程度分为:轻度肿胀组及中重度肿胀组;健康志愿者20人设为对照组。患者眼镜蛇咬伤后就诊时间差异分为A、B两组:A组(0 h≤患者眼镜蛇咬伤后时间8 h)与B组(患者眼镜蛇咬伤时间≥8 h);按年龄分组非老年组(年龄60岁)与老年组(年龄≥60岁)。检测患者及健康志愿者血清sPLA2水平,同时检测WBC、CRP、A-D-D及LAC水平。结果:1.对照组与眼镜蛇伤患者轻型组及重危组之间血清sPLA2水平之间均进行比较,轻型组及重危型组较对照组均明显升高,差异具有统计学意义并与患者病情严重程度成正相关。对照组、轻型组及重危组之间血LAC及WBC水平均进行比较,轻型组及重危型组较对照组均明显升高,差异具有统计学意义。对照组、轻型组及重危组之间血清A-D-D水平均进行比较,重危型组较对照组均明显升高,差异具有统计学意义。2.对照组与眼镜蛇伤患者轻度肿胀组及中重度肿胀组血清sPLA2水平均进行比较,轻度肿胀组及中重度肿胀组较对照组均明显升高,差异具有统计学意义并与患者病情严重程度成正相关。对照组、轻度肿胀组及中重度肿胀组血清LAC水平均进行比较,中重度肿胀组较对照组及较轻度肿胀组均明显升高,差异具有统计学意义。对照组、轻度肿胀组及中重度肿胀组血清A-D-D及WBC水平均进行比较,轻度肿胀组及中重度肿胀组较对照组均明显升高,差异具有统计学意义。3.对照组与眼镜蛇伤后患者就诊时间A组及B组之间血清sPLA2水平均进行比较,A组及B组较对照组均明显升高,差异具有统计学意义。对照组、A组及B组二组比较血LAC水、A-D-D、WBC水平均进行比较,A组及B组较对照组均明显升高,差异具有统计学意义。对照组、A组及B组之间血清CRP水平均进行比较,A组及B组较对照组均明显升高,升高且具有统计学意义,B组较A组明显升高,差异具有统计学意义,与患者就诊时间成正相关。4.患者sPLA2与LAC、A-D-D、WBC、CRP分别进行相关性分析,其相关系数分别为0.314、0.275、0.653、-0.056。结论:眼镜蛇伤后患者血清sPLA2水平升高,上升越高,病情越严重,肢体肿胀越重,坏死可能性越大。
[Abstract]:Objective: to analyze the changes of serum sPLA2 in patients with snake bite, and to explore the relationship between serum sPLA2 and the severity of cobra injury. Methods: from January 2015 to December 2015, 52 patients with eyeglass snake bite were admitted to the snake poisoning department of South China Hospital affiliated to South China University from January 2015 to December 2015. According to the degree of illness, the patients were divided into light and critical groups. The swelling degree of the affected limb after cobra bite was divided into mild swelling group and moderate and severe swelling group, and 20 healthy volunteers as control group. The difference of treatment time after cobra bite was divided into two groups: group A (0 h) and group B (8 h after cobra bite) and group B (the time of cobra bite 鈮，

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