关节腔内注射透明质酸钠治疗大骨节病疗效的Meta分析

发布时间：2018-05-14 18:06

本文选题：大骨节病 + 透明质酸钠　；参考：《中国循证医学杂志》2016年08期

【摘要】：目的系统评价关节腔内注射透明质酸钠治疗大骨节病的疗效。方法计算机检索Pub Med、EMbase、The Cochrane Library(2016年1期)、CBM、VIP、Wan Fang Data和CNKI数据库,搜集关节腔内注射透明质酸钠治疗大骨节病的相关随机对照试验(RCT),检索时限均为从建库至2016年1月。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果共纳入6个RCT,1 276例患者。Meta分析结果显示:与对照组相比,透明质酸钠组的临床优良率[OR=5.89,95%CI(4.10,8.47),P0.000 01]和Lequesne指数[SMD= 1.66,95%CI( 2.14, 1.13),P0.000 01]明显优于对照组,差异均有统计学意义。结论现有证据表明,关节腔内注射透明质酸钠可以改善临床优良率以及Lequesne指数。受纳入研究数量和质量的限制,上述结论尚需开展更多高质量的研究进一步验证。
[Abstract]:Objective to evaluate the efficacy of intraarticular injection of sodium hyaluronate in the treatment of Kaschin-Beck disease. Methods the Cochrane Library database of Pub Medbase was searched by computer. The random controlled trial of injecting sodium hyaluronate into articular cavity for the treatment of Kaschin-Beck disease was conducted. The search time was from the construction of the database to January 2016. Two researchers independently sifted the literature, extracted the data and evaluated the bias risks involved in the study. The Meta analysis was carried out with Rev Man 5.3 software. Results compared with the control group, the clinical excellent and good rates of sodium hyaluronate group [OR5.89 ~ 95CII 4.108.47 P0.00001] and the Lequesne index (2.14,1.13P0.00001) were significantly higher than those of the control group (2.14,1.13P0.00001). Conclusion the available evidence suggests that intraarticular injection of sodium hyaluronate can improve the clinical rate and Lequesne index. Due to the limitation of the quantity and quality of the research, more high-quality studies need to be carried out.
【作者单位】：四川大学华西医院老年医学中心/干部医疗科;
【基金】：国家“十一五”科技支撑计划重点项目(编号:2007 BAI 25 B 06)
【分类号】：R684.1

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