通过骨支架的数字化建模分析其力学性能与内部流场分布

发布时间：2018-05-16 10:06

本文选题：有效弹性模量 + 应力分布　；参考：《医用生物力学》2017年03期

【摘要】：目的研究不同骨支架结构的力学性能与内部流场分布,为模型结构的优劣提供直观上的比较和评判,为骨支架结构设计提供有效的指导方法。方法利用Pro/Engineer和MIMICS等软件重建自然结构骨支架、编织状骨支架和球形孔骨支架,并通过有限元方法分析3种支架的有效弹性模量、应力分布和三维灌注培养下支架内部流场分布。结果采用相同材料设计得到的自然结构骨支架表现出更小的有效弹性模量;当3种支架受到相同压力时,自然结构骨支架内部应力峰值更小且应力分布更均匀;初始流速和流体黏度相同时,自然结构骨支架表现出更小的内部流速、壁面剪切应力和壁面压力。结论自然结构骨支架模型具有相对较好的生物力学性能,在3种骨支架中最适合用于骨组织工程中骨支架结构选型。
[Abstract]:Objective to study the mechanical properties and internal flow field distribution of different bone scaffold structures in order to provide an intuitive comparison and evaluation for the merits and demerits of the model structures and to provide an effective guidance method for the design of bone scaffold structures. Methods the natural structure bone scaffold, braided bone scaffold and spherical pore bone scaffold were reconstructed by Pro/Engineer and MIMICS software. The effective elastic modulus, stress distribution and flow field distribution in the scaffold were analyzed by finite element method. Results the natural structure bone scaffold with the same material showed smaller effective elastic modulus, and the stress peak value was smaller and the stress distribution was more uniform when the three scaffolds were subjected to the same pressure. When the initial flow rate and fluid viscosity are the same, the natural structure bone scaffolds exhibit smaller internal velocity, wall shear stress and wall pressure. Conclusion the natural bone scaffold model has relatively good biomechanical properties and is the most suitable for bone scaffold selection in bone tissue engineering.
【作者单位】：上海大学快速制造工程中心;上海市智能制造及机器人重点实验室;
【基金】：国家自然科学基金项目(81201386)
【分类号】：R318.01;R68

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