前交叉韧带损伤与干细胞的治疗

发布时间：2018-05-18 19:57

本文选题：干细胞 + 间质干细胞　；参考：《中国组织工程研究》2017年21期

【摘要】：背景:有研究报道,前交叉韧带有着在非手术情况下康复的潜力,韧带的某些与细胞修复有关的细胞因子以及干细胞或祖细胞等生物因素影响着前交叉韧带的愈合。目的:综述间充质干细胞与前交叉韧带损伤治愈联系的相关文献,了解最终分化为前交叉韧带的干细胞/祖细胞的潜力,为利用间充质干细胞治疗前交叉韧带损伤提供依据。方法:第一作者检索Pub Med数据库的相关文献。检索词为"ACL regeneration stem/progenitor cells mesenchymal stem cells"。查阅近年来相关文献,包括综述、临床研究和基础研究,最终纳入45文献。结果与结论:近年来,对细胞治疗前交叉韧带损伤以及肌肉骨骼再生有了大量的研究,但是干细胞的使用还远远达不到日常临床治疗的需要,最适宜前交叉韧带再生的干细胞的来源以及它们最合适的注入点仍有待确定。尽管采用间充质干细胞治疗前交叉韧带损伤成功的例子已经在动物模型中报告,但仍然不清楚是否干细胞的营养因子可以改善再生或这些细胞自身可以形成新的组织。
[Abstract]:Background: it has been reported that anterior cruciate ligament (ACL) has the potential to recover in non-operative conditions. Some cytokines related to cell repair and biological factors such as stem cells or progenitor cells influence the healing of ACL. Aim: to review the relevant literature on the relationship between mesenchymal stem cells (MSCs) and anterior cruciate ligament injury (ACL) and to understand the potential of stem cell / progenitor cells which eventually differentiated into ACL so as to provide evidence for the treatment of ACL injury with mesenchymal stem cells (MSCs). Methods: the first author searched the literature of Pub Med database. The key word is "ACL regeneration stem/progenitor cells mesenchymal stem cells". Review related literature in recent years, including review, clinical research and basic research, and finally include 45 literature. Results & conclusion: in recent years, there has been a lot of research on cell therapy of anterior cruciate ligament injury and musculoskeletal regeneration, but the use of stem cells is far from the need of daily clinical treatment. The source of stem cells most suitable for anterior cruciate ligament regeneration and their optimal implantation sites have yet to be determined. Although successful cases of mesenchymal stem cells in the treatment of anterior cruciate ligament injury have been reported in animal models, it remains unclear whether the nutritional factors of stem cells can improve regeneration or whether the cells themselves can form new tissues.
【作者单位】：内蒙古医科大学;内蒙古医科大学第二附属医院;
【分类号】：R684

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