膝关节骨关节炎软骨中YKL-40、IL-1β的表达及相关性探讨

发布时间：2018-05-19 14:42

本文选题：骨关节炎 + 膝　；参考：《重庆医学》2017年04期

【摘要】：目的研究膝关节骨关节炎(KOA)病患软骨中甲壳质酶(YKL-40)、白细胞介素-1β(IL-1β)的表达水平,并分析两者相关性。方法选择该院骨科住院就诊的符合KOA诊断的病患38例,记为观察组。再选择同期因膝关节外伤行膝关节镜检治疗或膝关节骨折内固定手术患者关节软骨30例,记为对照组。根据KOA放射线及关节镜下分级标准,将观察组分为轻度组16例、中度组11例及重度组10例。对比所有病患的YKL-40、IL-1β、IL-6、肿瘤坏死因子-α(TNF-α)表达水平,同时进行Mankin评分、细胞死亡率的对比。结果观察组YKL-40、IL-1β、IL-6、TNF-α表达水平及Mankin评分、细胞死亡率均显著高于对照组,并且观察组中轻度、中度、重度的YKL-40等指标水平呈上升水平(均P0.05)。并且YKL-40表达水平与IL-1β水平存在显著的正相关(r=0.738,P=0.000)。此外,YKL-40表达水平还与IL-6(r=0.819,P=0.000)、TNF-α(r=0.871,P=0.000)表达水平及Mankin评分(r=0.832,P=0.000)、细胞死亡率存(r=0.832,P=0.000)在显著的正相关。结论 KOA病患中YKL-40、IL-1β呈高表达状态,并且两者呈现显著的正相关。
[Abstract]:Objective to study the expression of chitin, interleukin-1 尾 and IL-1 尾 in cartilage of patients with osteoarthritis of knee joint (KOAA), and to analyze the correlation between them. Methods 38 orthopaedic inpatients who were diagnosed by KOA were selected as observation group. 30 cases of articular cartilage were treated with arthroscopy or internal fixation of knee joint fracture in the same period, as control group. According to the criteria of KOA radiography and arthroscopy, the observation group was divided into mild group (n = 16), moderate group (n = 11) and severe group (n = 10). The expression levels of YKL-40, IL-1 尾 and TNF- 伪, Mankin score and cell death rate were compared in all patients. Results the expression of IL-6 TNF- 伪 and the Mankin score in the observation group were significantly higher than those in the control group, and the level of YKL-40 in the observation group was higher than that in the control group (all P 0.05). There was a significant positive correlation between the expression of YKL-40 and the level of IL-1 尾. In addition, the expression level of YKL-40 was positively correlated with the expression level of IL-6 ru (0.819) and TNF- 伪 0.871P ~ (0.000), Mankin score (r = 0.832) P ~ (0.000) and cell death rate (n = 0.832 ~ (2) P ~ (0.000). Conclusion the expression of YKL-40 and IL-1 尾 in KOA patients is high, and there is a significant positive correlation between the expression of YKL-40 and IL-1 尾.
【作者单位】：广东省肇庆市第一人民医院骨科;
【分类号】：R684.3

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