经皮椎体成形术与非手术治疗骨质疏松性椎体压缩骨折临床疗效的Meta分析

发布时间：2018-05-20 05:18

本文选题：骨质疏松 + 椎体压缩骨折　；参考：《山西医科大学》2015年硕士论文

【摘要】：目的:对比经皮椎体成形术(Percutaneous Vertebroplasty,PVP)和应用非手术治疗方式对于骨质疏松性椎体压缩骨折(OVCFs,Osteoporosis vertebral compressed fractures)的临床效果。方法:全面检索国内及国外近年来对于治疗OVCFs的所有文献资料,制定纳入资料标准和排除文献标准,并对选择的文献进行数据提取,用Review Manager 5.0软件进行Meta分析。检索年限:2000.1-2014.9。结果:共纳入六篇随机对照研究。Meta分析结果表明:与非手术治疗相比,PVP在术后的早期(MD=-1.88,95%CI(-0.32,-0.57),P=0.005)和长期(MD=-1.39,95%CI(-2.10,-0.69),P=0.001)均可以明显缓解疼痛,但是在RDQ功能评分(MD=-0.43,95%CI(-2.15,1.28),P=0.62)和EQ-5D生活质量评分(MD=-0.43,95%CI(-2.15,1.28),P=0.62)方面差异没有统计学意义,并且在新发椎体骨折率(RR=1.22,95%CI(0.72,2.08),P=0.47)和邻近椎体骨折率(RR=2.07,95%CI(0.95,4.45),P=0.07)方面差异亦没有统计学意义。结论:对于骨质疏松椎体压缩骨折,经皮椎体成形术是一种安全有效的治疗方法,能取得不错的临床效果。
[Abstract]:Objective: to compare the clinical effects of percutaneous Vertebroplasty (PVP) and nonoperative treatment for osteoporotic vertebral compression fractures (OVCs). Methods: all the literatures on treatment of OVCFs at home and abroad in recent years were searched, and the standards of inclusion and exclusion were established, and the selected documents were extracted and analyzed by Meta 5.0 software. Retrieval number of years: January 1 to 14 9. Results: the results of six randomized controlled trials. Meta-analysis showed that compared with non-operative treatment, PVP could significantly relieve pain in the early stage of operation, such as MD-1.88-95 CIQ -0.32U -0.57 P0.005) and long-term MD-1.39 + 95CI-2.10-0.69P0.001). However, there was no significant difference in the RDQ functional score (MD-0.43C95) and the EQ-5D score of quality of life (MD-0.43C95 CI-2.151.28CI-0.62), and there was no significant difference in the rate of newly developed vertebral body fracture (RR1.2295CII 0.722.08 P0.47) and the adjacent vertebral body fracture rate (RR2.0795 / 95) and the adjacent vertebral body fracture rate (RR2.0795 / 95 CI 0.954.45P0.07). The results showed that there was no significant difference between the two groups in terms of the new vertebral body fracture rate (RR1.229595) and the adjacent vertebral body fracture rate (RR2.07 / 95CI0.954.45P0.07). Conclusion: percutaneous vertebroplasty is a safe and effective treatment for osteoporotic vertebral compression fracture.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R687.3

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