肌少症、骨质疏松症的关系及研究进展

发布时间：2018-05-21 19:46

本文选题：肌少症 + 骨质疏松症　；参考：《中国骨质疏松杂志》2017年08期

【摘要】：随着人均寿命的延长,与肌肉骨骼系统相关疾病的发病率随之增长,国内外学者对肌少症、骨质疏松症的关注度也越来越高。肌少症是指与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退。骨质疏松症是以骨量减少、骨组织显微结构退化为特征,以至骨的脆性增高及骨折危险性增加的一种全身性骨病。肌少症、骨质疏松症是危害老年人健康的病理状态,使得老年人的生活质量大打折扣,患有肌少症的人群免疫功能、日常生活能力较常人降低,感染风险、跌倒风险、致残率、死亡风险较常人增加,患有骨质疏松症的人群跌倒风险、骨折风险、致残率也较常人高很多。肌少症与骨质疏松症相互影响、紧密关联的机制比较复杂,包括肌肉收缩力学负荷对骨骼机械力的影响,以及肌肉与骨骼间复杂精密内分泌调控的生物学机制。针对两者之间存在的许多共同危险因素及发病机制,进行运动干预、营养指导、药物治疗,有助于延缓肌少症、骨质疏松症的进展,改善不良预后。本文将结合国内外研究对两者概念、发病机制、临床表现、评估标准、干预及治疗等之间的相关关系及研究进展进行一一综述。
[Abstract]:With the prolongation of life expectancy, the incidence of musculoskeletal system related diseases increases. Scholars at home and abroad pay more and more attention to myopia and osteoporosis. Hypothyroidism refers to progressive age-related, systemic muscle loss and / or muscle strength decline or muscle physiological dysfunction. Osteoporosis is a kind of systemic bone disease characterized by the decrease of bone mass, the degeneration of bone microstructure, the increase of bone fragility and the increase of fracture risk. Myasthenia, osteoporosis is a pathological condition that endangers the health of the elderly, which greatly reduces the quality of life of the elderly. The immune function of the people suffering from myasthenia is lower than that of the normal people. The ability of daily living is lower than that of the normal people. The risk of infection, the risk of falling down, and the rate of disability. The risk of death is higher than that of normal people, and the risk of falling, fracture and disability is much higher in people with osteoporosis. The mechanism of closely related mechanism is complex, including the influence of muscle contraction mechanical load on skeletal mechanical force, and the biological mechanism of complex precise endocrine regulation between muscle and bone. In view of many common risk factors and pathogenesis between the two, exercise intervention, nutrition guidance and drug therapy can help to delay the progress of myasthenia and osteoporosis and improve the poor prognosis. This article will review the relationship between the two concepts, pathogenesis, clinical manifestations, evaluation criteria, intervention and treatment.
【作者单位】：南京医科大学附属苏州医院;
【分类号】：R580;R685

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