混合痔术后外用硝酸甘油软膏以止痛、促进愈合的疗效观察

发布时间：2018-05-28 04:09

本文选题：混合痔术后 + 硝酸甘油　；参考：《成都中医药大学》2015年硕士论文

【摘要】：目的：观察混合痔术后局部外用0.2%硝酸甘油软膏以止痛、促进愈合的临床疗效及药物不良反应。方法：选择符合纳入标准的混合痔患者50例,随机分为治疗组和对照组,治疗组、对照组各25例。自术后第2日开始,予治疗组患者0.2%硝酸甘油软膏局部外用,每日3次；对照组患者不使用硝酸甘油软膏；两组其他术后常规治疗相同。观察并对比两组患者术后疼痛、肛缘水肿、便血、外痔切口愈合及药物不良反应情况。结果：(1)术后第3、4、5日治疗组肛门静息疼痛评分小于对照组(P0.05),术后第2日、第6日两组肛门静息疼痛评分无统计学差异； (2)术后治疗组排便疼痛持续天数小于对照组(P0.05)； (3)术后肛缘水肿情况两组无统计学差异；(4)术后继发性出血情况两组无统计学差异：(5)术后治疗组外痔切口愈合所需时间小于对照组(P0.05)；(6)对照组无不良反应发生；治疗组药物不良反应发生率为20.0%,主要表现为轻度头痛、疲劳感、肛门灼热,多可自行缓解；无严重不良反应发生。结论：混合痔术后局部外用0.2%硝酸甘油软膏能够缓解术后第3至5日肛门静息疼痛,能够缩短术后排便疼痛持续天数以及外痔切口的愈合所需时间,未体现处预防术后水肿的确切疗效,未见加重术后继发性出血的迹象,不良反应症状轻微,主要表现为轻度头痛、疲劳感、肛门灼热,一般可自行缓解,药物耐受性良好。
[Abstract]:Objective: to observe the clinical effect and adverse drug reaction of local topical application of 0.2% nitroglycerin ointment to relieve pain and promote healing after mixed hemorrhoids operation. Methods: 50 cases of mixed hemorrhoids were randomly divided into treatment group and control group, 25 cases in treatment group and 25 cases in control group. Since the 2nd day after operation, the patients in the treatment group were given 0.2% nitroglycerin ointment for topical use three times a day; the patients in the control group did not use nitroglycerin ointment; the other routine treatment was the same in the two groups. Postoperative pain, anal edema, hematochezia, incision healing of external hemorrhoids and adverse drug reactions were observed and compared between the two groups. Results the anus resting pain score in the treatment group was lower than that in the control group on the 4th and 5th day after operation (P 0.05). There was no significant difference in anal resting pain score between the two groups on the 6th day; (2) the duration of postoperative defecation pain in the treatment group was less than that in the control group (P 0.05); (3) there was no statistical difference between the two groups in anal edema after operation; (4) there was no postoperative secondary bleeding in the two groups. The time required for incision healing of external hemorrhoids in the treatment group was less than that in the control group (P 0.05). There was no adverse reaction in the control group. In the treatment group, the incidence of adverse drug reactions was 20.0. The main symptoms were mild headache, fatigue, burning anus, most of which could be alleviated by themselves, and no serious adverse reactions occurred. Conclusion: local topical application of 0.2% nitroglycerin ointment for mixed hemorrhoids can relieve anal resting pain from the 3rd to 5th day after operation, shorten the duration of postoperative defecation pain and the time needed to heal the incision of external hemorrhoids. The exact effect of preventing edema after operation was not reflected, and the signs of secondary hemorrhage after operation were not seen. The symptoms of adverse reaction were mild, mainly manifested as mild headache, fatigue, anal burning, general self-relief, good drug tolerance.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R657.18

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