右美托咪定改善合并中度慢性阻塞性肺疾病肺癌手术患者的肺氧合功能

发布时间：2018-05-29 14:06

本文选题：右美托咪定 + 单肺通气　；参考：《中南大学学报(医学版)》2017年03期

【摘要】：目的:探索右美托咪定是否能改善合并中度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)肺癌手术患者肺氧合作用和肺呼吸力学参数。方法:将56名合并有中度COPD的肺癌手术患者随机分配到对照组或Dex组(每组n=28)。单肺通气期间,Dex组右美托咪定初始负荷剂量为1.0μg/kg,微量泵注10 min,随后维持剂量改为0.5μg/kg,持续泵注1 h。对照组采用同样方法给予相同容量的0.9%生理盐水。结果:Dex组的氧合指数明显高于对照组(P0.05),在Dex-30和Dex-60时肺动态顺应性明显增加(P0.05)。Dex组的术后氧合指数显著升高(P=0.025),术后并发症明显减少。结论:对合并有中度COPD的肺癌手术患者,右美托咪定能够提高肺氧合指数,改善肺呼吸力学参数和减少术后肺部并发症。
[Abstract]:Objective: To explore whether right metodetomidine can improve pulmonary oxygen cooperation and pulmonary respiratory mechanics parameters in patients with moderate chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) lung cancer surgery. Methods: 56 patients with moderate COPD in lung cancer were randomly assigned to a control group or a Dex group (each group of n=28). In group Dex, the initial load dose of dexmedetomidine in group Dex was 1 u g/kg, micropump was 10 min, then the dosage was changed to 0.5 mu g/kg, and the same method was given to 0.9% physiological saline of the same capacity in the continuous pump 1 h. control group. Results: the oxygenation index of the Dex group was significantly higher than that of the control group (P0.05), and the lung dynamic compliance was significantly increased at Dex-30 and Dex-60. P0.05) the postoperative oxygenation index increased significantly in group.Dex (P=0.025), and postoperative complications were significantly reduced. Conclusion: right metomomidin can improve pulmonary oxygenation index, improve pulmonary respiratory mechanics parameters and reduce postoperative pulmonary complications for patients with moderate COPD lung cancer.
【作者单位】：苏州大学临床医学院;江南大学附属医院(无锡市第四人民医院)麻醉科;第二军医大学附属东方肝胆外科医院;上海交通大学附属仁济医院麻醉科;
【基金】：无锡市卫生和计划生育委员会基金(MS201517) 无锡市医院管理中心课题(YGZXY1307)~~
【分类号】：R614

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