硅凝胶治疗增生性瘢痕Meta分析

发布时间：2018-05-30 20:38

  本文选题：硅凝胶 + 增生　； 参考：《中国皮肤性病学杂志》2017年01期

【摘要】：目的评价硅凝胶治疗增生性瘢痕的有效性及安全性。方法计算机检索Cochrane图书馆临床对照试验数据库、MEDLINE光盘数据库、相关期刊论文及万方数据库。筛选应用硅凝胶治疗增生性瘢痕,对照组为空白或安慰剂的随机或临床对照试验,使用Cochrane协作网提供的Rev Man 5.0软件对纳入文献进行统计分析。主要评价指标为瘢痕厚度,次要指标包括瘢痕弹性、颜色、并发症发生率及疼痛和瘙痒等。结果硅凝胶治疗在缩小瘢痕厚度[RR=-1.62,95%CI=(-2.70,-0.55),P=0.003],改善瘢痕颜色[RR=2.17,95%CI=(1.09,4.35),P=0.03]及疼痛和瘙痒等[RR=3.00,95%CI=(1.19,7.54),P=0.02]方面优于对照组,但其对瘢痕弹性改善与对照组差异无统计学意义[RR=3.03,95%CI=(1.02,8.99),P=0.05],且其并发症发生率较对照组高[RR=9.21,95%CI=(2.6,32.67),P=0.000 6]。结论硅凝胶在改善增生性瘢痕厚度、颜色及患者主观评价方面可能具有一定的疗效,但在改善瘢痕弹性方面并无显著疗效,且并发症发生率高于对照组。本次研究由于纳入的研究质量普遍不高,结果存在一定的偏倚性,尚不能得出硅凝胶对增生性瘢痕疗效优于对照组的结论。
[Abstract]:Objective to evaluate the efficacy and safety of silicone gel in the treatment of hypertrophic scar. Methods the Cochrane library clinical controlled trial database was searched by computer, including MEDLINE CD-ROM database, Chinese periodical full-text database and Wanfang database. Silica gel was used to treat hypertrophic scar. The control group was a blank or placebo randomized or clinical controlled trial. The statistical analysis of the literature was carried out using Rev Man 5.0 software provided by Cochrane cooperation network. The main evaluation measures were scar thickness, and the secondary indexes included scar elasticity, color, incidence of complications, pain and pruritus. 缁撴灉纭呭嚌鑳舵不鐤楀湪缂╁皬鐦㈢棔鍘氬害[RR=-1.62,95%CI=(-2.70,-0.55),P=0.003],鏀瑰杽鐦㈢棔棰滆壊[RR=2.17,95%CI=(1.09,4.35),P=0.03]鍙婄柤鐥涘拰鐦欑棐绛塠RR=3.00,95%CI=(1.19,7.54),P=0.02]鏂归潰浼樹簬瀵圭収缁，

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