中药塌渍联合关节腔注射玻璃酸钠治疗膝骨性关节炎（风寒湿痹型）的临床研究

发布时间：2018-06-03 03:10

本文选题：膝骨性关节炎 + 中药溻渍疗法　；参考：《长春中医药大学》2015年硕士论文

【摘要】：目的:膝关节骨性关节炎是一种常见的慢性关节疾病,好发于中老年人,严重影响中老年人的身体健康及生活质量。本次研究通过临床观察中药塌渍联合关节腔注射玻璃酸钠治疗风寒湿痹型膝关节骨性关节炎的临床疗效,试图为临床治疗膝关节骨性关节炎提供一种简单而行之有效的中西医结合治疗方法提供依据。方法:本研究所采用病例均来自长春中医药大学附属医院骨科住院部患者,共60例。住院期间为2013年11月至2015年1月,且均符合相应的膝骨性关节炎诊断纳入标准及相关标准;纳入后整体采用随机分组原则,分为治疗组与对照组,两组各30例。治疗组给予外敷中药塌渍并关节腔内注射玻璃酸钠治疗;对照组给予外用贴覆精致狗皮膏并关节腔内注射玻璃酸钠治疗。经过2个疗程1个观察周期后,对各组的治疗情况与膝关节改善情况分别进行汇总与评分,以评价总体疗效。根据膝关节骨性关节炎疾病特点及患者自身情况,本研究评定标准采用2002年《中药新药临床研究指导原则》的中医证候评分标准、1976年美国特种外科医院(HSS)的膝关节功能评分标准、视觉模拟评分表(VAS)分别给予评分,并将汇总后所有数据经spssl7.0统计软件进行结果分析,以便客观评价治疗后两种疗法的总体疗效。结果:治疗组与对照组治疗后在中医证候改善方面比较分析可见(P0.05),说明治疗组在中医证候改善方面疗效好于对照组;另外根据(HSS)的膝关节功能评分标准在疼痛、关节功能改善、关节活动度等方面(P0.05),表明治疗组疗效也较对照组有优势;最后进行整体疗效对比经秩和检验Z=-2.981,P0.05,表示两组之间差异有统计学意义,结果说明治疗组整体疗效明显优于对照组。结论:经临床研究比较得出中药溻渍联合关节腔注射玻璃酸钠疗法在治疗膝关节骨性关节炎方面疗效显著,效果独到,为中西医结合疗法治疗膝骨性关节炎提供了新思路,也为后续开发高效、价廉、操作简便的治疗方法提供了理论依据。
[Abstract]:Objective: osteoarthritis of knee joint is a common chronic joint disease. In this study, we observed the clinical curative effect of the treatment of rheumatism and dampness arthralgia type osteoarthritis of knee joint with traditional Chinese medicine cavities and intraarticular injection of sodium hyaluronate. This paper attempts to provide a simple and effective method for the treatment of knee osteoarthritis. Methods: 60 cases of orthopedic patients from affiliated Hospital of Changchun University of traditional Chinese Medicine were enrolled in this study. The period of hospitalization was from November 2013 to January 2015, and all of them met the relevant criteria for the diagnosis of osteoarthritis of the knee, and were divided into treatment group and control group with 30 cases in each group. The treatment group was treated with external application of traditional Chinese medicine and intraarticular injection of sodium hyaluronate, while the control group was treated with external application of refined canine skin ointment and intraarticular injection of sodium hyaluronate. After two courses of treatment and one observation cycle, the treatment and knee joint improvement in each group were summarized and scored respectively to evaluate the overall curative effect. According to the characteristics of knee osteoarthritis disease and the patient's own condition, The evaluation criteria of this study were based on the criteria of TCM syndromes score of 2002 "guiding principles of Clinical Research of New drugs of traditional Chinese Medicine", the knee joint function score of American Special surgery Hospital (HSS) in 1976 and visual analogue scale (VAS), respectively. All the data were analyzed by spssl7.0 software in order to evaluate the overall curative effect of the two treatments objectively. Results: the improvement of TCM syndromes in the treatment group and the control group was compared with that in the control group, indicating that the curative effect of the treatment group was better than that of the control group in the improvement of TCM syndromes, in addition, according to the score of knee joint function of HSS, pain and joint function were improved. The results showed that the therapeutic effect of the treatment group was better than that of the control group, and the overall curative effect of the treatment group was better than that of the control group by rank sum test. Conclusion: compared with the clinical study, it is concluded that the treatment of traditional Chinese medicine Tachia and intraarticular injection of sodium hyaluronate is effective and unique in the treatment of knee osteoarthritis, which provides a new idea for the treatment of knee osteoarthritis by the combination of traditional Chinese and Western medicine. It also provides a theoretical basis for the further development of effective, inexpensive and simple treatment methods.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R684.3

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