低强度脉冲超声联合药物治疗创伤性膝关节骨性关节炎的临床研究

发布时间：2018-06-05 13:04

本文选题：低强度脉冲超声波 + 创伤性膝关节骨性关节炎　；参考：《中国康复医学杂志》2016年08期

【摘要】：目的:观察低强度脉冲超声(low intensity pulsed ultrasound,LIPUS)联合药物治疗对创伤性膝关节骨性关节炎(traumatic knee osteoarthritis,TKOA)的临床治疗效果。方法:将60例TKOA患者随机分为联合组、对照1组和对照2组,20例/组。联合组:予LIPUS联合口服非甾体类抗炎药(NSAIDs)治疗;对照1组:予单纯LIPUS治疗;对照2组:予单纯口服NSAIDs治疗。分别在治疗前后,进行3组间的VAS评分、(Western Ontario and Mc Master universities osteoarthritis index,WOMAC)评分、(Lysholm knee score,LKSS)评分;并经MRI检查行ICRS标准分级,测量膝关节内外侧髁、髌软骨外侧、内侧软骨T2值。结果:经6周治疗后,三组VAS评分、WOMAC评分、LKSS评分均较治疗前有不同程度的改善,联合组疗效明显优于对照1组(P0.05)和对照2组(P0.05),对照1组优于对照2组,但无显著性意义(P0.05);三组MRI检查T2值结果无论与检查前比较,还是三组间比较均未见明显治疗效果(P0.05)。结论:LIPUS联合药物治疗可改善TKOA患者的临床症状和/或体征,可一定程度的提高患者的膝关节功能,但对依据MRI检查的TKOA患者膝关节软骨的损害或退变程度无明显关联性。
[Abstract]:Objective: to observe the clinical effect of low intensity pulsed ultrasound (LIPUS) combined with medicine on traumatic knee osteoarthritis (TKOAA). Methods: 60 patients with TKOA were randomly divided into two groups: control group (n = 20), control group (n = 20) and control group (n = 20). The combined group was treated with LIPUS combined with oral NSAIDs, the control group was treated with LIPUS alone and the control group with oral NSAIDs. Before and after treatment, the three groups were divided into three groups: Western and Mc master universities osteoarthritis index and WOMAC) scores, and MRI examination was performed to measure the T _ 2 values of the medial and lateral condyle, lateral patellar cartilage and medial articular cartilage. Results: after 6 weeks of treatment, the VAS score and WOMAC score and LKSS score of the three groups were improved to some extent, and the curative effect of the combined group was significantly better than that of the control group 1 (P 0.05) and the control group 2 (P 0.05), the control group 1 was superior to the control group 2 (P 0.05), and the control group 1 was superior to the control group 2. However, there was no significant difference between the three groups in terms of the T _ 2 value of MRI, and no significant therapeutic effect was found in the three groups either before or between the three groups. Conclusion the clinical symptoms and / or signs of TKOA patients can be improved by using the combined drug therapy of TKOA, and the knee joint function can be improved to some extent, but there is no significant correlation between the damage or degeneration degree of articular cartilage in TKOA patients based on MRI.
【作者单位】：南京医科大学附属南京医院(南京市第一医院)康复医学科;
【基金】：南京市医学科技发展基金项目(YKK13113)
【分类号】：R684.3

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