骨关节结核患者TNF-α、TGF-β炎症因子表达分析

发布时间：2018-06-08 02:18

本文选题：骨关节结核 + 转化生长因子-β　；参考：《基因组学与应用生物学》2017年06期

【摘要】：为了分析骨关节结核患者TNF-α、TGF-β炎症因子的表达及其临床应用价值,本研究以我院2015年1月~2016年9月期间收治的50例骨关节结核患者为研究对象,按骨关节结核病变分为增生性病变组和干酪性病变组,分析两组患者血清TNF-α、TGF-β炎症因子阳性表达差异;以30例健康人群为对照组,分析TNF-α、TGF-β对骨质骨量的影响。结果表明,TNF-α、TGF-β在不同病变骨关节结核组织中呈现高低不同的阳性表达,TNF-α、TGF-β在增生性病变结核组织中的表达水平显著高于干酪性病变结核组织中的表达水平(p0.05),TNF-α、TGF-β在增生性病变的坏死性结核组织中和非坏死性结核组织中的表达水平无明显差异性(p0.05),但TNF-α、TGF-β在干酪性病变的坏死性结核组织中的表达水平显著高于干酪性病变的非坏死性结核组织中的表达水平(p0.05)。增生性病变患者和干酪性病变患者的骨关节结核组织中的成骨细胞数均明显低于正常人(p0.05),而破骨细胞数则明显高于正常人(p0.05),增生性病变患者骨关节结核组织中的成骨细胞数明显低于干酪性病变患者(p0.05),而破骨细胞数则明显高于干酪性病变患者(p0.05)。由此可知,骨关节结核患者TNF-α、TGF-β炎症因子在不同病变骨关节结核组织中存在不同程度的表达,对患者病情发展及患者骨质骨量均有着重要的影响。
[Abstract]:In order to analyze the expression and clinical value of TNF- 伪 TGF- 尾 inflammatory factor in patients with osteoarticular tuberculosis, 50 patients with osteoarticular tuberculosis admitted in our hospital from January 2015 to September 2016 were studied. The positive expression of TNF- 伪 TGF- 尾 and TNF- 伪 TGF- 尾 in the serum of patients with osteoarticular tuberculosis were analyzed, and the effect of TNF- 伪 TGF- 尾 on bone mass was analyzed in 30 healthy controls. The results showed that the expression of TNF- 伪 TGF- 尾 in tuberculous tissues of different lesions was significantly higher than that in caseous tuberculous tissues of proliferative lesions. The expression level of TNF- 伪 TGF- 尾 in proliferative tuberculous tissues was significantly higher than that in caseous tuberculous tissues of osteoarticular tuberculosis. [WT5HZ] the expression level of TNF- 伪 and TGF- 尾 in tuberculous tissues with proliferative lesions was significantly higher than that in caseous tuberculous tissues. There was no significant difference in the expression of TNF- 伪 and TGF- 尾 between necrotic tuberculosis and non-necrotizing tuberculosis, but the expression level of TNF- 伪 TGF- 尾 in caseous necrotic tuberculous tissue was significantly higher than that in caseous lesion. The expression level in nuclear tissue was p0.05. The number of osteoblasts in osteoarticular tuberculosis tissues in proliferative lesions and caseous lesions was significantly lower than that in normal controls, while the number of osteoclasts in osteoclasts was significantly higher than that in normal controls. The number of osteoblasts in osteoarticular tuberculosis in hyperplastic lesions was significantly higher than that in osteoarticular tuberculosis. The number of osteoblasts was significantly lower than that of caseous lesions, while the number of osteoclasts was significantly higher than that of caseous lesions. Therefore, the expression of TNF- 伪 -TGF- 尾 inflammatory factor in different lesions of osteoarticular tuberculosis is different, which has an important effect on the development of the disease and the bone mass of the patients.
【作者单位】：深圳市第三人民医院;
【基金】：深圳市第三人民医院提供项目资助
【分类号】：R529.2

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