中国新疆地区腰椎管狭窄患者腰椎黄韧带肥厚的危险因素分析:回顾性、单中心、病例分析

发布时间：2018-06-10 17:15

本文选题：组织工程 + 腰椎　；参考：《中国组织工程研究》2017年19期

【摘要】：背景:黄韧带肥厚是引起椎管狭窄的重要原因之一,目前多数学者认为在CT、MRI上测量黄韧带厚度4 mm即可诊断为肥厚,但对于肥厚的原因及分布特点尚无研究。有研究显示,L2/3,L3/4,L4/5和L5/S1所有节段的黄韧带厚度均与年龄呈正相关,而是否与民族、性别及肥胖等因素有关则少有研究报道。目的:回顾性分析中国新疆地区腰椎管狭窄患者腰椎黄韧带肥厚的危险因素。方法:研究为回顾性、单中心、病例分析,在中国新疆医科大学第六附属医院完成。回顾性收集2012年5月至2016年5月在新疆医科大学第六附属医院就诊的腰椎管狭窄104例患者的腰椎CT影像学资料进行数据分析。试验的主要观察指标为CT测量的不同民族、性别、身高、年龄、体质量患者的腰椎黄韧带厚度变化。次要结局指标为CT测量的不同民族、性别、身高、年龄及体质量患者的腰椎形态;民族、性别、身高、年龄及体质量与患者黄韧带厚度的相关性;影响黄韧带肥厚相关因素的多元线性回归分析结果。试验在北美临床试验注册中心作回顾性注册(NCT03057353)。研究方案已取得新疆医科大学第六附属医院伦理委员会的批准,且符合世界医学会制订的《赫尔辛基宣言》。参与者本人对试验方案和过程均知情同意,并签署知情同意书。讨论:试验拟通过CT测量新疆地区腰椎管狭窄患者腰椎黄韧带厚度,观察不同民族、性别、身高、年龄及体质量的新疆地区腰椎管狭窄症患者黄韧带厚度的变化规律,并分析导致黄韧带肥厚的危险因素,为临床预防新疆地区黄韧带肥厚所致的腰椎管狭窄提供量化参考数据。
[Abstract]:Background: hypertrophy of ligamentum flavum is one of the important causes of spinal canal stenosis. At present, most scholars think that measuring 4 mm thickness of ligamentum flavum on CT MRI can be diagnosed as hypertrophy, but there is no study on the cause and distribution of hypertrophy. Studies have shown that the thickness of ligamentum flavum in all segments of L2 / 3 / 4 / 4 / 5 and L5 / S1 is positively correlated with age, but there are few studies on whether the thickness of ligamentum flavum is related to nationality, sex and obesity. Objective: to retrospectively analyze the risk factors of lumbar ligamentum flavum hypertrophy in patients with lumbar spinal stenosis in Xinjiang, China. Methods: the study was carried out in the sixth affiliated Hospital of Xinjiang Medical University. From May 2012 to May 2016, 104 patients with lumbar spinal stenosis who were admitted to the sixth affiliated Hospital of Xinjiang Medical University were collected and analyzed retrospectively. The main outcome measures were measured by CT in patients with different nationalities, sex, height, age, body mass and the thickness of lumbar ligamentum flavum. The secondary outcome indexes were different nationalities, sex, height, age and body mass of lumbar vertebrae measured by CT, and the correlation between nationality, sex, height, age and weight of ligamentum flavum and the thickness of ligamentum flavum. Multivariate linear regression analysis of factors related to ligamentum flavum hypertrophy. The trial was retrospectively registered at the North American Clinical trial Registry (NCT03057353). The research program has been approved by the Ethics Committee of the sixth affiliated Hospital of Xinjiang Medical University and is in accordance with the Helsinki Declaration formulated by the World Medical Association. Participants themselves have informed consent and signed informed consent to the trial program and process. Discussion: Ct was used to measure the thickness of ligamentum flavum in lumbar spinal stenosis patients in Xinjiang, and to observe the changes of ligamentum flavum thickness in patients with lumbar spinal stenosis in Xinjiang with different nationalities, sex, height, age and body mass. The risk factors leading to hypertrophy of ligamentum flavum were analyzed to provide quantitative reference data for clinical prevention of lumbar spinal canal stenosis caused by hypertrophy of ligamentum flavum in Xinjiang.
【作者单位】：新疆医科大学第六附属医院脊柱外二科;
【基金】：新疆维吾尔自治区自然科学基金(2016D01C221)~~
【分类号】：R681.5

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