经皮椎体成形术联合唑来膦酸治疗糖皮质激素诱导骨质疏松性椎体压缩骨折的研究

发布时间：2018-06-11 09:41

本文选题：糖皮质激素类 + 骨质疏松　；参考：《重庆医学》2017年35期

【摘要】：目的探讨糖皮质激素(GCs)诱导骨质疏松性椎体压缩骨折患者采用经皮椎体成形术(PVP)联合唑来膦酸治疗的效果。方法选取2013年1月至2015年6月该院收治的82例GCs诱导骨质疏松性椎体压缩骨折患者,根据患者入院顺序分为唑来膦酸组与对照组(各41例),唑来膦酸组予以PVP联合唑来膦酸治疗,对照组予以PVP联合利塞磷酸治疗,比较两组患者的治疗效果。结果术后1周两组患者的椎体前缘高度、椎体后缘高度较术前均明显提高(P0.05),椎体后凸角测定值较术前明显降低(P0.05);术前、术后1周两组间椎体前缘高度、椎体后缘高度、椎体后凸角测定值比较,差异均无统计学意义(P0.05)。治疗3、6个月,唑来膦酸组患者血清Ⅰ型前胶原羧基端肽β特殊序列(β-CTX)、Ⅰ型前胶原氨端肽原(PINP)水平均低于对照组(P0.05),骨密度值高于对照组(P0.05);术后两组患者Oswestry功能障碍指数均较术前明显降低(P0.05);术后6个月,唑来膦酸组患者Oswestry功能障碍指数低于对照组(P0.05)。结论 GCs诱导骨质疏松性椎体压缩骨折患者采用PVP联合唑来膦酸治疗有利于改善患者的骨质疏松情况,促进功能恢复。
[Abstract]:Objective to investigate the effect of percutaneous vertebroplasty (PVP) combined with zoledronic acid in the treatment of osteoporotic vertebral compression fractures induced by glucocorticoid (GCS). Methods from January 2013 to June 2015, 82 patients with GCs induced osteoporotic vertebral compression fractures were selected. According to the admission order, the patients were divided into zoledronic acid group (n = 41) and control group (n = 41). The patients in the control group were treated with zoledronic acid combined with zoledronic acid, and the patients in the control group were treated with PVP combined with Lise phosphoric acid. Results at 1 week after operation, the anterior height and posterior height of vertebral body in both groups were significantly higher than those before operation (P 0.05), the kyphosis angle of vertebral body was significantly lower than that of preoperation, and the anterior height of vertebral body and the height of posterior edge of vertebral body between the two groups before and 1 week after operation were significantly lower than those before operation. There was no significant difference in kyphosis angle between the two groups (P 0.05). Treatment for 3, 6 months, In zoledronic acid group, the serum levels of procollagen type I carboxyl terminal peptide 尾 (尾 -CTXN) were lower than those of control group (P 0.05), and the bone mineral density (BMD) was higher than that of control group (P 0.05), and the Oswestry dysfunction index of the two groups after operation was higher than that before operation. After 6 months of operation, P0. 05 was significantly decreased. The Oswestry dysfunction index in zoledronic acid group was lower than that in control group (P 0.05). Conclusion the treatment with PVP combined with zoledronic acid in patients with osteoporotic vertebral compression fracture induced by GCs can improve the condition of osteoporosis and promote the recovery of function.
【作者单位】：青海省西宁市第二人民医院骨科;
【分类号】：R580;R687.3

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