不同添加成分对自体移植脂肪细胞活性的影响:进展与现状

发布时间：2018-06-11 16:32

本文选题：脂肪细胞 + 移植　；参考：《中国组织工程研究》2017年32期

【摘要】：背景:自体脂肪组织没有排异性,由于其来源相对丰富,成本相对低廉,移植后外观相对自然,目前已成为近乎理想的组织填充物。目的:文章就近年来不同添加成分对脂肪细胞活性影响的研究进展做一综述。方法:以"Autologousadipose tissue;rate of survival;stromal vascular fraction;platelet-rich plasma;growth factor;adipose derived stem cells;leptin"为英文检索词,以"脂肪细胞,成活率,自体脂肪移植,基质血管成分,富血小板血浆,生长因子,脂肪来源干细胞,瘦素"为中文检索词。应用计算机检索中国知网全文数据库、万方全文数据库、维普期刊全文数据库、Pub Med数据库、Elsevier数据库、Embase数据库有关脂肪细胞活性的文献,保留47篇文献进一步总结分析。结果与结论:自体脂肪组织移植还存在一些缺陷,研究发现单纯颗粒脂肪移植后存活率低于60%,移植后脂肪组织吸收率较高,可能出现囊肿、钙化等一系列并发症,这些都制约着自体脂肪移植的广泛临床应用。国内外学者一直在试图通过改进吸脂方法、冻存条件,或采用不同添加成分如富血小板血浆、血管基质成分等等不同方法,以提高脂肪移植成活率。其中血管基质成分、富血小板血浆、脂肪来源干细胞、A型肉毒毒素、部分细胞因子已有临床研究证实其可行及有效性,瘦素、部分生长因子及药物的研究仍需从动物模型转入临床实验的研究。
[Abstract]:Background: autogenous adipose tissue has no heterogeneity, because of its relatively rich sources, relatively low cost and relatively natural appearance after transplantation, autologous adipose tissue has become an almost ideal tissue filler. Aim: to review the effects of different additives on adipocyte activity in recent years. Methods: the Chinese key words were "Autologousadipose tissue rate of survival stromal vascular fractionator platelet-rich growth factor adipose derived stem cellsleptin" and "adipocyte, survival rate, autologous fat transplantation, matrix vascular component, platelet-rich plasma, growth factor, adipose derived stem cell, leptin". The full text database of China Zhiwang, Wanfang full text database and the full text database of Weip periodical are searched by computer. The database of Elsevier / Elsevier / Embase database is related to adipocyte activity, and 47 articles are further summarized and analyzed. Results and conclusion: there are some defects in autologous adipose tissue transplantation. It was found that the survival rate of autogenous fat grafts was lower than that of 60 grafts, the absorption rate of adipose tissue was higher after transplantation, and a series of complications, such as cysts, calcification and so on, might occur. All these restrict the wide clinical application of autologous fat transplantation. Scholars at home and abroad have been trying to improve the liposuction method, freezing conditions, or using different additives such as platelet-rich plasma, vascular matrix components and other different methods to improve the survival rate of fat transplantation. Among them, vascular matrix, platelet-rich plasma, adipose-derived stem cell type A botulinum toxin, some cytokines have been clinically proven to be feasible and effective, leptin, Some studies of growth factors and drugs still need to be transferred from animal models to clinical trials.
【作者单位】：大连医科大学;郑州大学医学院;大连医科大学美容医学院;
【分类号】：R622

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