右美托咪定注射液对甲状腺手术患者术后镇痛作用的影响

发布时间：2018-06-11 19:55

本文选题：舒芬太尼 + 右美托咪定　；参考：《中国临床药理学杂志》2017年11期

【摘要】：目的观察右美托咪定注射液对甲状腺手术术后镇痛作用的临床疗效及安全性。方法将102例甲状腺肿瘤进行甲状腺手术的患者随机分为对照组与试验组,每组51例。2组患者均于手术切皮前给予舒芬太尼10μg+0.375%罗派卡因混合液20 m L,术后给予盐酸格拉司琼注射液5 mg,每日1次,静脉滴注。对照组术前给予咪达唑仑注射液0.03 mg·kg~(~(-1)),静脉泵注;试验组术前给予盐酸右美托咪定注射液1μg·kg~(~(-1)),静脉泵注。比较2组患者的临床疗效、血清人β内啡肽(β-EP)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)水平及药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为92.16%(47/51例)和78.43%(40/51例),差异有统计学意义(P0.05)。治疗后,对照组和试验组人β内啡肽分别为(268.47±29.58),(284.47±30.05)pg·L~(~(-1));CRP分别为(4.47±0.54),(4.07±0.42)mg·L~(~(-1)),差异均有统计学意义(均P0.05)。试验组的药物不良反应有嗜睡、呼吸抑制、恶心呕吐,药物不良反应发生率为5.88%(3/51例);对照组的药物不良反应有瘙痒、呼吸抑制、嗜睡、恶心呕吐,药物不良反应发生率为11.76%(6/51例),差异无统计学意义(P0.05)。结论右美托咪定注射液对甲状腺手术术后镇痛作用的临床疗效显著,且安全性高。
[Abstract]:Objective to observe the clinical efficacy and safety of dexmetomidine injection in postoperative analgesia of thyroid surgery. Methods 102 patients undergoing thyroid surgery were randomly divided into control group and experimental group. Patients in each group were given sufentanil 10 渭 g 0.375% ropivacaine 20 mL before skin incision, and granisetron hydrochloride injection 5 mg per day after operation. The control group received midazolam injection (0.03 mg / kg) by intravenous pump before operation, while the test group received dexmetomidine hydrochloride injection (1 渭 g / kg) intravenously before operation. The clinical efficacy, serum 尾 -EP (尾 -EPN) level and the incidence of adverse drug reactions (ADR) were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 92.16 / 47 / 51 and 78.43 / 40 / 51, respectively. The difference was statistically significant (P 0.05). After treatment, the levels of 尾 -endorphin in the control group and the experimental group were 268.47 卤29.58 and 284.47 卤30.05)pg / L, respectively, and were 4.47 卤0.54 and 4.07 卤0.42)mg / L, respectively. The difference was statistically significant (P 0.05). The adverse drug reactions in the trial group were somnolence, respiratory depression, nausea and vomiting, and the incidence of adverse drug reactions was 5.88 / 51 cases, while in the control group, the adverse drug reactions were itching, respiratory inhibition, lethargy, nausea and vomiting. The incidence of adverse drug reactions was 11.76 / 51 with no significant difference (P 0.05). Conclusion dexmetomidine injection is effective and safe in postoperative analgesia of thyroid surgery.
【作者单位】：台州医院麻醉科;
【基金】：台州市计划课题基金资助项目(1401ky06)
【分类号】：R614

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