骨血管生成机制与功能的研究进展

发布时间：2018-06-16 00:00

本文选题：血管生成 + 骨形成　；参考：《中国现代医学杂志》2017年27期

【摘要】：骨骼是高度血管化的组织,依赖于血管和骨细胞之间的密切关系,以维持骨骼完整性。因此,血管生成在骨骼发育、修复和重塑中起关键作用。骨血管是为骨细胞传递氧、营养素、激素、神经递质和生长因子等的主要通道,骨血管还参与协调造血过程。骨毛细血管可以区分出两种亚型,包括位于干骺端的H型和在骨干的骨髓腔中形成毛细管网的L型。已有研究表明,血管生成和骨形成的过程是偶联的,这其中涉及多种细胞因子、信号通路及micro RNA的参与。该研究回顾关于骨血管的结构、功能和相关调节因素的最新数据,特别强调血管生成和血管功能在骨发育和再生中的作用及其在骨折愈合和骨组织工程中的应用。
[Abstract]:Bone is highly vascularized tissue, dependent on the close relationship between blood vessels and bone cells to maintain bone integrity. Therefore, angiogenesis plays a key role in bone development, repair and remodeling. Bone vessels are the main channels for the transmission of oxygen, nutrients, hormones, neurotransmitters and growth factors to bone cells. Bone vessels are also involved in the coordination of hematopoietic processes. Bone capillaries can be distinguished into two subtypes: type H located in metaphysis and type L forming capillary network in the medullary cavity of the diaphysis. Studies have shown that angiogenesis and bone formation are coupled, involving a variety of cytokines, signaling pathways and micro RNAs. The study reviewed the latest data on the structure, function and related regulatory factors of bone vessels, with particular emphasis on the role of angiogenesis and vascular function in bone development and regeneration and their applications in fracture healing and bone tissue engineering.
【作者单位】：南京中医药大学骨伤修复与重建新技术实验室;
【基金】：江苏省高校研究生科研创新计划项目(No:KYZZ16_0409) 江苏省金坛市科研计划项目(No:JT2013070)
【分类号】：R68

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