氨酚羟考酮在腰椎后路融合术后的镇痛效果观察

发布时间：2018-06-18 08:04

本文选题：腰椎后路融合术 + 术后镇痛　；参考：《中国药房》2017年11期

【摘要】：目的:观察氨酚羟考酮在腰椎后路融合术后的镇痛效果,优选脊柱术后镇痛方案。方法:采用回顾性研究方法,选择湖北医药学院附属人民医院2013年6月-2014年6月收治的120例腰椎后路融合术患者资料,按治疗方案不同分为观察组和对照组,各60例。观察组患者在术后6 h口服氨酚羟考酮330 mg;术后第1、2天口服氨酚羟考酮330 mg,tid。对照组患者在术后6 h口服塞来昔布200 mg;术后第1、2天口服塞来昔布200 mg,bid。观察术后两组患者静息状态和活动状态下的镇痛效果[视觉模拟评分法(VAS)评分]、术后胃肠运动功能恢复情况(肛门排气时间)和不良反应发生情况。结果:无论是在静息状态下还是在活动状态下,观察组患者术后24、48、72、120 h的VAS评分均显著低于对照组,差异均有统计学意义(P0.05)。两组患者的肛门排气时间和不良反应发生率比较,差异均无统计学意义(P0.05)。结论:口服氨酚羟考酮对解除脊柱术后疼痛具有较好的效果,且镇痛快速、安全。
[Abstract]:Aim: to observe the analgesic effect of aminophenol hydroxycodone after lumbar posterior fusion. Methods: a retrospective study was conducted on 120 patients with posterior lumbar fusion in the people's Hospital affiliated to Hubei Medical College from June 2013 to June 2014. The patients were divided into observation group (n = 60) and control group (n = 60). The patients in the observation group were given 330mg of paracetamol hydroxycodone at 6 hours after operation and 330mg / d of paracetamol hydroxycodone on the 1st day after operation. The patients in control group were given celecoxib 200 mg at 6 h and celecoxib 200 mg bid 2 days after operation. The analgesic effect (visual analogue score), the recovery of gastrointestinal motor function (anal exhaust time) and the occurrence of adverse reactions were observed in the two groups. Results: the VAS scores of the patients in the observation group were significantly lower than those in the control group at 24: 48 and 72 120 h after operation, both in the resting state and in the active state, and the difference was statistically significant (P 0.05). There was no significant difference in anal exhaust time and incidence of adverse reactions between the two groups (P 0.05). Conclusion: oral administration of aminophenol hydroxycodone has a good effect on relieving postoperative spinal pain, and analgesia is rapid and safe.
【作者单位】：湖北医药学院附属人民医院脊柱外科;第三军医大学第三附属医院脊柱外科;
【分类号】：R687.3

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