化疗对乳腺癌患者血糖和中医证候的影响

发布时间：2018-06-26 07:11

本文选题：血糖 + 化疗　；参考：《北京中医药大学》2015年硕士论文

【摘要】：本文包括文献综述和临床研究两部分。第一部分是文献综述,主要介绍了本课题研究的背景,即恶性肿瘤与糖尿病关系的研究进展,主要包括以下几部分：1.西医对恶性肿瘤合并糖尿病的研究现状,包含肿瘤和糖尿病的基本概念、流行病学,糖尿病继发恶性肿瘤的发病机制,糖尿病治疗药物继发恶性肿瘤的可能机制,恶性肿瘤继发糖尿病的可能机制,化疗等肿瘤治疗方式对血糖的影响；2.中医对恶性肿瘤病因病机的认识,中医对糖尿病病因病机的认识,中医对恶性肿瘤合并糖尿病的认识。第二部分为临床研究,题目为化疗对乳腺癌患者的血糖与中医证候的影响。目的：主要进行以下方面探讨：(1)化疗对乳腺癌患者空腹血糖的影响；(2)化疗对乳腺癌患者中医证型的影响；(3)影响化疗后空腹血糖的相关因素。主要方法：采用回顾性统计分析的研究方法,分析2014年1月1日至2014年12月31日中日友好医院中西医结合肿瘤内科收治的31例乳腺癌患者,统计化疗前后的中医证型、血糖、年龄、肝功能情况,分析化疗对血糖和中医证候的影响,以及化疗方案、基础血糖、年龄、肝功能情况与化疗前后血糖变化的相关性。结果：1.化疗后的血糖明显高于化疗前(P0.01),具有统计学意义14人出现一过性空腹血糖升高；2.基础空腹血糖、年龄、肝功与化疗后空腹血糖有统计学差异(P0.05)；3.不同化疗方案相比对化疗后空腹血糖影响无统计学差异(P0.05)。4.化疗前单证以气郁证、血瘀证为主,化疗后以血瘀证、气虚证为主,化疗后气虚证、血虚证、阴虚证较化疗前增加。结论：1.化疗后的血糖明显高于化疗前,化疗可导致空腹血糖异常；2.基础空腹血糖、年龄、肝功是化疗后空腹血糖相关因素；3.化疗方案对化疗后空腹血糖无影响；4.化疗后气虚证、血虚证、阴虚证较化疗前增加。
[Abstract]:This article includes two parts: literature review and clinical research. The first part is a literature review, mainly introduces the background of this research, that is, the relationship between malignant tumor and diabetes, mainly includes the following parts: 1: 1. The current research status of western medicine on malignant tumor with diabetes mellitus, including the basic concepts of cancer and diabetes, epidemiology, the pathogenesis of diabetes secondary malignant tumor, the possible mechanism of diabetes treatment drug secondary malignant tumor, The possible mechanism of diabetes secondary to malignant tumor and the effect of chemotherapy and other cancer treatment methods on blood sugar. The understanding of the etiology and pathogenesis of malignant tumor, the etiology and pathogenesis of diabetes, and the understanding of malignant tumor complicated with diabetes in TCM. The second part is clinical research on the effect of chemotherapy on blood sugar and TCM syndrome of breast cancer patients. Objective: to explore the following aspects: (1) the effect of chemotherapy on fasting blood glucose in patients with breast cancer; (2) the effect of chemotherapy on TCM syndromes of patients with breast cancer; (3) the related factors affecting fasting blood glucose after chemotherapy. Methods: by retrospective statistical analysis, 31 patients with breast cancer admitted from January 1, 2014 to December 31, 2014 in the Department of Oncology of Integrated Chinese and Western Medicine in Sino-Japanese Friendship Hospital were analyzed. The TCM syndromes and blood glucose before and after chemotherapy were analyzed. The influence of chemotherapy on blood sugar and TCM syndromes, as well as the correlation between chemotherapy scheme, basic blood sugar, age, liver function and blood glucose before and after chemotherapy were analyzed. The result is 1: 1. The blood glucose after chemotherapy was significantly higher than that before chemotherapy (P0.01). Basic fasting blood glucose, age, liver function and fasting blood glucose after chemotherapy were significantly different (P0.05). There was no significant difference in the effect of different chemotherapy regimens on fasting blood glucose after chemotherapy (P0.05). 4. Before chemotherapy, Qi stagnation syndrome, blood stasis syndrome, Qi deficiency syndrome, blood deficiency syndrome and yin deficiency syndrome were more than before chemotherapy. Conclusion 1. The blood glucose after chemotherapy was significantly higher than that before chemotherapy, and chemotherapy could lead to abnormal fasting blood glucose. Basic fasting blood glucose, age and liver function are related factors of fasting blood glucose after chemotherapy. Chemotherapy regimen had no effect on fasting blood glucose after chemotherapy. Qi deficiency syndrome, blood deficiency syndrome and yin deficiency syndrome increased after chemotherapy.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.9

【参考文献】