止血绫修复内镜黏膜下剥离术后创面的应用研究

发布时间：2018-06-28 22:01

本文选题：内镜黏膜下剥离术 + 动物模型　；参考：《中国内镜杂志》2017年05期

【摘要】：目的探讨止血绫在内镜黏膜下剥离术(ESD)后预防创面出血及创面修复中的临床应用价值。方法采用活体兔对比研究手术切开兔胃后的出血量(ml),并以活体猪为研究对象行结肠ESD手术,实验组术后用止血绫进行覆盖,对照组创面则不予以处理,术后3天、1周、2周及4周分别进行内镜及病理学检查,比较两组的创面出血及组织愈合情况。结果兔胃出血量对比实验中,实验组出血量明显低于对照组,实验猪行结肠ESD术后创面均成功覆盖止血绫。行内镜检查及病理检查,实验组存在修复优势。实验组与对照组总共24处创面中,均未出现感染、穿孔等实验相关的不良事件。结论止血绫在临床ESD后创面修复中具有潜在的应用价值。
[Abstract]:Objective to explore the clinical value of preventing bleeding and repairing of wound after endoscopic submucosal dissection (ESD). Methods the volume of hemorrhage (ML) after the operation of the rabbit's stomach was compared with the living rabbit, and the colonic ESD operation was performed on the living pig. The experimental group was covered with hemostasis after the operation, and the wounds in the control group were no longer in the control group. Endoscopic and pathological examination were performed at 3 days, 1 weeks, 2 and 4 weeks after operation, and the bleeding and tissue healing of the two groups were compared. Results in the experimental group, the bleeding volume of the experimental group was significantly lower than that of the control group. The wound of the experimental pig's colon after ESD was successfully covered with hemostasis. There were 24 wounds in the experimental group and the control group, and there were no adverse events related to the infection and perforation. Conclusion the hemostatic damask has potential application value in the repair of wound surface after clinical ESD.
【作者单位】：厦门大学附属东南医院(解放军第175医院)消化内科;
【基金】：南京军区医学科技创新重点项目(No:15ZD026) 吴阶平医学基金会临床科研专项资助基金(No:320.6750.1523) 175医院多学科项目(No:14LYG002) 南京军区医学科技创新面上项目(No:15MS109) 175医院青年苗圃课题(No:16Y002)
【分类号】：R656

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