经皮椎体后凸成形术对老年骨质疏松性脊柱骨折患者血清CTX-Ⅰ、IGF、睾酮水平和生活质量的影响

发布时间：2018-07-01 19:25

本文选题：经皮椎体成形术 + 经皮椎体后凸成形术　；参考：《中国老年学杂志》2017年23期

【摘要】：目的探讨经皮椎体后凸成形术(PKP)对老年骨质疏松性脊柱骨折患者血清Ⅰ型胶原C端异物肽(CTX)-Ⅰ、胰岛素样生长因子(IGF)、睾丸(T)水平和生活质量的影响。方法回顾性分析该院接受手术治疗的60例老年骨质疏松性脊柱骨折患者的临床资料,根据手术方法的不同分为经皮椎体成形术(PVP)组28例和PKP组32例,于手术前和手术后1 w、3个月采用视觉模拟量表(VAS)和Oswestry功能障碍指数(ODI)评价两组疼痛程度和功能状况,并测量两组伤椎Cobb角,观察两组骨水泥渗漏情况,于手术前和手术后12个月检测两组血清CTX-Ⅰ、IGF和T水平,并采用健康状况调查量表(SF-36)评价两组手术前和手术后12个月的生活质量。结果两组手术后1 w、3个月VAS评分和ODI值比较差异无统计学意义(P0.05);PKP组手术后1 w、3个月伤椎Cobb角均小于PVP组(P0.05);PKP组手术后12个月血清CTX-Ⅰ水平低于PVP组血清IGF和T水平均高于PVP组(均P0.05);PKP组手术后12个月社会功能和情感职能评分均显著高于PVP组(P0.05);PKP组骨水泥渗漏率明显低于PVP组(P0.05)。结论 PVP和PKP用于老年骨质疏松性脊柱骨折患者,可有效缓解患者的疼痛症状,改善生活质量。PKP在矫正脊柱后凸畸形和改善骨质疏松方面具有更好的效果。
[Abstract]:Objective to investigate the effect of percutaneous kyphoplasty (PKP) on serum C end foreign body peptide (CTX) - I, insulin like growth factor (IGF), testicular (T) level and quality of life in elderly patients with osteoporotic spinal fractures. Methods a retrospective analysis of 60 cases of elderly osteoporotic spinal fractures treated by hand surgery in this hospital was reviewed. Data were divided into 28 cases of percutaneous vertebroplasty (PVP) and 32 cases in group PKP. Before and after 1 W, two groups of pain and function were evaluated by visual analogue scale (VAS) and Oswestry dysfunction index (ODI), and two groups of vertebral Cobb angles were measured, and two groups of bone cement leakage were observed and the operation was performed. The serum CTX- I, IGF and T levels were measured in two groups before and 12 months after the operation, and the quality of life before and 12 months after operation was evaluated with the health status survey scale (SF-36). The results were not statistically significant (P0.05) between the 1 W and 3 months after operation in the two groups, and 3 months after the operation (P0.05), and 1 W in the PKP group and 3 months after the operation were less than PVP. Group (P0.05); the level of serum CTX- I in group PKP 12 months after operation was lower than that in group PVP, IGF and T water was higher than that of group PVP (P0.05). The scores of social function and emotional function of group PKP were significantly higher than that of PVP group (P0.05) in group PKP after operation, and the leakage rate of bone cement in PKP group was significantly lower than that of group PVP (P0.05). The patients can effectively relieve the pain symptoms and improve the quality of life..PKP has a better effect in correcting kyphosis and improving osteoporosis.
【作者单位】：萍乡市人民医院脊柱外科;
【分类号】：R580;R687.3

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