辛伐他汀调控内源性干细胞进行退变椎间盘的内源性修复和重建

发布时间：2018-07-05 03:55

本文选题：缺氧诱导因子 + 间质干细胞　；参考：《中国组织工程研究》2017年05期

【摘要】：背景:研究显示,他汀类药物能够促进椎间盘细胞骨形态发生蛋白2、聚集蛋白聚糖及Ⅱ型胶原等细胞外基质m RNA达,同时也能使已去分化的髓核细胞表型发生逆转,从而能减缓椎间盘退变过程。目的:综述近年来国内外研究辛伐他汀诱导干细胞生物学活性及动员内源性干细胞修复退变椎间盘的研究进展。方法:由第一作者检索至2016年1月为止Pub Med及CNKI相关期刊论文,以"椎间盘退变治疗,内源性干细胞和退变的椎间盘,辛伐他汀和干细胞"等为检索词,共检索102篇相关文献,排除重复研究,共48篇文献符合纳入标准。结果与结论:综合大量国内外科研人员对椎间盘退变治疗的研究,发现辛伐他汀可以促进低氧诱导因子1α的表达,同时低氧诱导因子1α又可以调控退变的椎间盘组织中的髓核间充质干细胞的生物学行为。因此,辛伐他汀能够通过此途径来进行退变椎间盘的内源性修复和重建。
[Abstract]:Background: studies have shown that statins can promote bone morphogenetic protein 2, aggregation proteoglycan and type II collagen extracellular matrix mRNA, but also reverse the phenotype of dedifferentiated nucleus pulposus cells. This can slow down the process of disc degeneration. Aim: to review the recent progress in the research on the biological activity of simvastatin induced stem cells and the mobilization of endogenous stem cells to repair degenerative intervertebral disc. Methods: the full text databases of Pub Med and CNKI Chinese journals were searched by the first author until January 2016. The key words were "disc degeneration therapy, endogenous stem cells and degenerated intervertebral discs, simvastatin and stem cells". A total of 102 related articles were retrieved and 48 articles met the inclusion criteria. Results & conclusion: a large number of researchers at home and abroad have studied the treatment of intervertebral disc degeneration and found that simvastatin can promote the expression of hypoxia inducible factor-1 伪. At the same time, hypoxia inducible factor 1 伪 can regulate the biological behavior of nucleus pulposus mesenchymal stem cells in degenerative intervertebral disc. Therefore, simvastatin can be used for endogenous repair and reconstruction of degenerative intervertebral disc.
【作者单位】：扬州大学医学院扬州大学临床医学院;
【基金】：国家自然科学基金(青年基金项目,81401830) 中国博士后科学基金资助(2015M571714) 江苏省自然科学基金(青年基金项目,BK 20140496)~~
【分类号】：R681.53

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