系统康复训练配合神经节苷脂对脊髓损伤患者生活自理能力及血清炎性因子水平的影响

发布时间：2018-07-15 08:53

【摘要】：目的探讨系统康复训练配合神经节苷脂对脊髓损伤患者生活自理能力及血清炎性因子水平的影响。方法选取经诊断为脊髓损伤患者78例,按照随机数字表法分为对照组与观察组各39例。对照组采用常规的系统康复训练,观察组在对照组的基础上给予患者静脉滴注单唾液酸四己糖神经节苷脂钠,以30 d为1个治疗周期,共进行2个周期的治疗。采用日常生活活动能力评定(Barthel)量表、焦虑自评量表(SAS)和抑郁自评量表(SDS)评价治疗前后两组生活自理能力及情绪,采用酶联免疫吸附法(ELISA)检测治疗前后两组血清白细胞介素(IL)-8、IL-1β、肿瘤坏死因子(TNF)-α含量。结果治疗后两组Barhel指数均显著升高,且观察组显著高于对照组(P0.05),治疗后观察组SDS及SAS评分均较治疗前显著降低,且显著低于对照组(均P0.05),治疗后两组IL-8、IL-1β、TNF-α含量均显著降低,且观察组显著低于对照组(P0.05)。结论系统康复训练配合神经节苷脂可以有效提高脊髓损伤患者的日常生活自理能力,缓解患者的抑郁及焦虑的负面情绪,降低血清IL-8、IL-1β及TNF-α水平,对脊髓损伤患者的治疗具有一定疗效。
[Abstract]:Objective to investigate the effects of systematic rehabilitation training combined with ganglioside on self-care ability and serum inflammatory factors in patients with spinal cord injury. Methods Seventy-eight patients with spinal cord injury were randomly divided into control group (n = 39) and observation group (n = 39). The control group was treated with routine systematic rehabilitation training, and the observation group was treated by intravenous infusion of tetrahexose monosialate ganglioside sodium on the basis of the control group. The treatment period was 30 days and the treatment period was 2 cycles. The activity of daily living (Barthel) scale, self rating anxiety scale (SAS) and self rating depression scale (SDS) were used to evaluate the ability of living and emotion before and after treatment. The serum levels of interleukin (IL) -8 and IL-1 尾 and tumor necrosis factor (TNF)-伪 were measured by enzyme linked immunosorbent assay (Elisa) before and after treatment. Results after treatment, the Barhel index in both groups was significantly higher than that in the control group (P0.05). After treatment, the SDS and SAS scores in the observation group were significantly lower than those in the control group (P0.05). After treatment, the contents of IL-8, IL-1 尾 and TNF- 伪 in the two groups were significantly lower than those in the control group (P0.05). The observation group was significantly lower than the control group (P0.05). Conclusion systematic rehabilitation training combined with ganglioside can effectively improve the self-care ability of daily life of patients with spinal cord injury, alleviate the negative emotion of depression and anxiety, and decrease the levels of IL-8, IL-1 尾 and TNF- 伪 in patients with spinal cord injury. The treatment of spinal cord injury patients has certain curative effect.
【作者单位】：徐州市第一人民医院骨科;
【基金】：江苏大学2014年度医学临床科研发展基金项目(No.JLY20140125)
【分类号】：R651.2

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