终板软骨细胞退变相关信号通路的研究进展
发布时间：2018-07-15 21:12
【摘要】：正椎间盘退变性疾病是临床常见病和多发病,目前研究认为,影响椎间盘退变的主要因素有炎症反应、氧化应激和机械应力等~[1~3]。在这些因素的作用下,椎间盘软骨终板发生病理性改变,出现终板钙化,导致营养物质弥散障碍,是椎间盘退变的始动因素~[4],而终板软骨细胞肥大、凋亡在终板钙化中起主要作用~[5]。但目前对软骨细胞退变的
[Abstract]:Degenerative disease of positive intervertebral disc is a common and frequent disease in clinic. At present, the main factors influencing degeneration of intervertebral disc are inflammatory reaction, oxidative stress and mechanical stress. Under the action of these factors, the endplate of the intervertebral disc has pathological changes and calcification of the endplate, which leads to nutrient dispersion disorder, which is the initiator of disc degeneration, and the endplate chondrocytes are hypertrophic. Apoptosis plays a major role in calcification of endplate. But at present, the degeneration of chondrocytes
【作者单位】： 广州中医药大学研究生院;广州中医药大学第一附属医院脊柱骨科;
【分类号】：R681.5
本文编号：2125398
[Abstract]:Degenerative disease of positive intervertebral disc is a common and frequent disease in clinic. At present, the main factors influencing degeneration of intervertebral disc are inflammatory reaction, oxidative stress and mechanical stress. Under the action of these factors, the endplate of the intervertebral disc has pathological changes and calcification of the endplate, which leads to nutrient dispersion disorder, which is the initiator of disc degeneration, and the endplate chondrocytes are hypertrophic. Apoptosis plays a major role in calcification of endplate. But at present, the degeneration of chondrocytes
【作者单位】： 广州中医药大学研究生院;广州中医药大学第一附属医院脊柱骨科;
【分类号】：R681.5
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