三阴乳腺癌组织PTEN蛋白表达变化及与患者预后的关系

发布时间：2018-07-20 20:18

【摘要】：目的观察三阴乳腺癌组织同源性磷酸酶-张力蛋白(PTEN)的表达变化,并探讨其与患者预后的关系。方法选择三阴乳腺癌组织标本80例份、乳腺纤维腺瘤正常乳腺组织石蜡标本25例份,采用免疫组化法检测二者PTEN蛋白表达。对80例三阴乳腺癌患者进行随访,记录无病生存期及总生存期。用Cox多因素回归分析三阴乳腺癌患者预后的影响因素。结果乳腺癌组织PTEN阳性表达率低于正常乳腺组织(P0.05)。临床分期为Ⅰ、Ⅱ期的三阴乳腺癌患者,其组织中PTEN蛋白阳性表达率高于临床分期Ⅲ、Ⅳ期患者(P0.05);发生淋巴结转移的三阴乳腺癌患者,其组织中PTEN蛋白阳性表达率低于未发生淋巴结转移的患者(P0.05)。PTEN蛋白表达阴性的三阴乳腺癌患者术后1、2、5年生存率均低于PTEN蛋白表达阳性患者(P均0.05)。Cox多因素回归分析结果显示,肿瘤直径、淋巴结转移、临床分期及PTEN蛋白表达是三阴乳腺癌患者5年无瘤生存的独立影响因素(P均0.05)。结论三阴乳腺癌组织中PTEN蛋白呈低表达;PTEN蛋白表达阴性的三阴乳腺癌患者预后差。
[Abstract]:Objective to investigate the expression of homologous phosphatase-tension protein (PTEN) and its relationship with prognosis in patients with triple yin breast cancer. Methods the expression of PTEN protein was detected by immunohistochemical method in 80 cases of breast cancer and 25 cases of normal breast tissue of fibroadenoma. The disease-free survival and total survival were recorded in 80 patients with triple negative breast cancer. Cox multivariate regression analysis was used to analyze the prognostic factors of patients with triple negative breast cancer. Results the positive expression rate of PTEN in breast cancer was lower than that in normal breast (P 0.05). The positive expression rate of PTEN protein in patients with stage 鈪，

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