严重创伤失血多器官功能不全综合征患者胰岛β细胞功能与感染炎症和主要脏器功能的相关性
发布时间：2018-07-28 14:50
【摘要】：目的分析严重创伤失血多器官功能不全综合征(MODS)患者胰岛β细胞功能与感染炎症及主要脏器功能之间的关系。方法选取2013年1月至2016年1月解放军第九四医院住院部收治的各种创伤MODS患者187例,按结局分为MODS生存组(MODS-S组,104例)和MODS病死组(MODS-D组,83例);另选取同期体检健康者100例作为对照组。测定3组空腹时血糖(GLU0)和胰岛素(INS0)水平,糖负荷30 min后血糖(GLU30)和胰岛素(INS30)水平,以及血可溶性髓样细胞触发受体-1(sTREM-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、丙氨酸氨基转移酶(ALT)、肌酐(Cre)和肌酸激酶同工酶(CK-MB)等指标水平;以稳态模式评估法胰岛素分泌指数(HOMA-β)和糖负荷30min后胰岛素增量和血糖增量比值(ΔINS30/ΔGLU30)评估胰岛β细胞功能,并分析与其他各项指标的关系。结果 MODS-D组HOMA-β和ΔINS30/ΔGLU30均明显低于MODS-S组,sTREM-1、TNF-α、IL-6、ALT、Cre、CK-MB水平均明显高于MODS-S组,差异均有统计学意义(P0.01);严重创伤失血MODS患者HOMA-β和ΔINS30/ΔGLU30分别与血sTREM-1、TNF-α、IL-6、GLU0、ALT、Cre及CK-MB呈明显负相关(r=-0.356 4、-0.532 1、-0.345 8、-0.772 1、-0.762 5、-0.684 8、-0.606 4,r=-0.428 5、-0.567 8、-0.487 0、-0.743 6、-0.781 7、-0.717 6、-0.640 1,P0.01)。结论严重创伤失血MODS患者存在胰岛β细胞功能不全,可以作为患者预后的诊断指标。
[Abstract]:Objective to analyze the relationship between islet 尾 cell function and infection inflammation and main organ function in (MODS) patients with severe traumatic haemorrhage multiple organ dysfunction syndrome. Methods from January 2013 to January 2016, 187 MODS patients with various trauma were selected. According to the outcome, the patients were divided into MODS survival group (MODS-S group, 104 cases) and MODS group (MODS-D group, 83 cases), and 100 healthy persons in the same period as control group. Fasting blood glucose (GLU0) and insulin (INS0) were measured in three groups, and blood glucose (GLU30) and insulin (INS30) were measured after 30 min of glucose load. Serum soluble myeloid cell trigger receptor 1 (sTREM-1), tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6), alanine aminotransferase (ALT),) creatinine (Cre) and creatine kinase isoenzyme (CK-MB) were also measured. Insulin secretion index (HOMA- 尾) and insulin increment and glucose increment ratio (螖 INS30/ 螖 GLU30) after glucose load 30min were evaluated by homeostasis model method, and the relationship between insulin secretion index (HOMA- 尾) and other indexes was analyzed. 缁撴灉 MODS-D缁凥OMA-尾鍜屛擨NS30/螖GLU30鍧囨槑鏄句綆浜嶮ODS-S缁，
本文编号：2150590
[Abstract]:Objective to analyze the relationship between islet 尾 cell function and infection inflammation and main organ function in (MODS) patients with severe traumatic haemorrhage multiple organ dysfunction syndrome. Methods from January 2013 to January 2016, 187 MODS patients with various trauma were selected. According to the outcome, the patients were divided into MODS survival group (MODS-S group, 104 cases) and MODS group (MODS-D group, 83 cases), and 100 healthy persons in the same period as control group. Fasting blood glucose (GLU0) and insulin (INS0) were measured in three groups, and blood glucose (GLU30) and insulin (INS30) were measured after 30 min of glucose load. Serum soluble myeloid cell trigger receptor 1 (sTREM-1), tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6), alanine aminotransferase (ALT),) creatinine (Cre) and creatine kinase isoenzyme (CK-MB) were also measured. Insulin secretion index (HOMA- 尾) and insulin increment and glucose increment ratio (螖 INS30/ 螖 GLU30) after glucose load 30min were evaluated by homeostasis model method, and the relationship between insulin secretion index (HOMA- 尾) and other indexes was analyzed. 缁撴灉 MODS-D缁凥OMA-尾鍜屛擨NS30/螖GLU30鍧囨槑鏄句綆浜嶮ODS-S缁，
本文编号：2150590
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