椎间盘内源性干细胞在椎间盘组织修复再生中的研究进展

发布时间：2018-08-02 18:29

【摘要】：目的总结近年椎间盘内源性干细胞的相关研究进展,讨论利用内源性干细胞修复治疗椎间盘退行性疾病的潜在可能性。方法查阅近年椎间盘内源性干细胞参与椎间盘组织修复再生的相关文献,分析椎间盘内源性干细胞的修复再生潜能,总结体外提取和培养椎间盘内源性干细胞的方法,并展望其临床应用前景。结果椎间盘组织内存在干细胞巢,内源性干细胞在微环境改变下归巢或迁移至受损组织,并参与组织的修复再生;椎间盘内源性干细胞的迁移募集活动能够被趋化因子系统所诱导。椎间盘的组织特异性干细胞逐渐得到确认,并成功分离、培养与鉴定,为椎间盘内源性干细胞的临床应用奠定了基础。结论椎间盘内源性干细胞在椎间盘组织修复再生中发挥重要作用,基于椎间盘内源性干细胞的生物学修复策略具有广阔应用前景。
[Abstract]:Objective to summarize the recent advances in endogenous stem cells of intervertebral disc and discuss the potential of using endogenous stem cells to repair intervertebral disc degenerative diseases. Methods the related literatures on endogenous stem cells of intervertebral disc involved in the repair and regeneration of intervertebral disc were reviewed in recent years, the potential of repair and regeneration of endogenous stem cells of intervertebral disc were analyzed, and the methods of extraction and culture of endogenous stem cells of intervertebral disc in vitro were summarized. The prospect of its clinical application is also prospected. Results there were stem cell nests in intervertebral disc tissue. Endogenous stem cells were homing or migrating to damaged tissue under microenvironment change and participated in tissue repair and regeneration. The migration and recruitment of endogenous stem cells of intervertebral disc can be induced by chemokine system. Tissue specific stem cells of intervertebral disc were gradually confirmed, isolated, cultured and identified successfully, which laid a foundation for clinical application of endogenous stem cells of intervertebral disc. Conclusion the endogenous stem cells of intervertebral disc play an important role in the repair and regeneration of intervertebral disc, and the biological repair strategy based on the endogenous stem cells of intervertebral disc has a broad application prospect.
【作者单位】： 华中科技大学同济医学院附属协和医院骨科医院;
【基金】：科技部国家重点研发计划资助项目(2016YFC1100100)~~
【分类号】：R681.5
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本文编号：2160325