开放性创伤手术切口感染患者血清炎性因子水平变化分析

发布时间：2018-08-02 16:58

【摘要】：目的探讨开放性创伤手术切口感染患者血清炎性因子水平变化分析,为临床诊断以及对相关实验室检查指标选择提供依据。方法选取2012年9月-2014年3月因腹部创伤发生感染的住院患者90例为感染组,同期行甲状腺切除术的未感染患者80例为非感染组,同期健康体检者80名为对照组,对感染和非感染组患者的临床资料进行调查,包括患者年龄、手术时间、手术后伤口感染的程度、术后是否出现伤口周围组织坏死,对各组中性粒细胞绝对值(ANC)、多形核粒细胞CD64(PMNCD64)、血清可溶性CD86(CD86)和亲环素A(CyPA)水平及血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化进行比较。结果各组ANC水平中感染组患者体内的ANC水平要明显高于非感染组和对照组,差异有统计学意义(P0.05);对于PMNCD64的水平显示,感染组患者明显高于其他两组,差异有统计学意义(P0.05);对于sCD86的水平,其感染组患者水平要明显高于对照组(P0.05),对照组和非感染组两组之间比较,差异无统计学意义;CyPA水平比较,感染组和对照组之间差异有统计学意义(P0.05),其他两组之间差异无统计学意义,同时感染组和非感染组之间差异无统计学意义;ANC与PMNCD64存在正相关性(P0.01);感染组患者的CRP、TNF-α、IL-6等炎性因子阳性率分别为97.8%、92.2%、95.6%,显著高于对照组患者的3.75%、2.5%、3.75%,差异有统计学意义(P0.05)。结论开放性创伤手术感染患者血清相关炎性因子会显著升高,因此,对开放性创伤手术切口感染患者进行相关炎性指标的监测有重要的意义。
[Abstract]:Objective to investigate the changes of serum inflammatory factors in patients with open wound infection, and to provide evidence for clinical diagnosis and the selection of laboratory indicators. Methods from September 2012 to March 2014, 90 inpatients with abdominal trauma were selected as infected group, 80 uninfected patients undergoing thyroidectomy and 80 healthy persons as control group. The clinical data of infected and non-infected patients were investigated, including age, duration of operation, degree of wound infection after operation, postoperative necrosis of tissue around the wound. The absolute value of neutrophil (ANC), polymorphonuclear CD64 (PMNCD64), serum soluble CD86 (CD86) and cyclophile A (CyPA), serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor- 伪 (TNF- 伪) were compared. Results the level of ANC in infected group was significantly higher than that in non-infection group and control group (P0.05). The level of PMNCD64 in infected group was significantly higher than that in other two groups (P0.05). The difference was statistically significant (P0.05); for the level of sCD86, the level of patients in the infected group was significantly higher than that in the control group (P0.05), but there was no significant difference between the two groups in the control group and the non-infected group. The difference between the infection group and the control group was statistically significant (P0.05), but there was no significant difference between the other two groups. There was no significant difference between the infection group and the non-infection group (P0.01), and the positive rate of inflammatory factors such as CRP- TNF- 伪 IL-6 in the infected group was 97.8% and 92.22%, respectively, which was significantly higher than that in the control group (3.75%), the difference was statistically significant (P0.05). Conclusion the serum levels of inflammatory cytokines in patients with open wound surgery infection are significantly increased, so it is of great significance to monitor the related inflammatory indexes in patients with open wound surgery infection.
【作者单位】：海口市人民医院伤口造口中心;
【基金】：海南省卫生厅科研基金资助项目(琼卫2014-21)
【分类号】：R619.3

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