复方蜈蚣颗粒在慢性跟骨骨髓炎腓肠神经营养血管皮瓣转移术后的应用

发布时间：2018-08-04 11:19

【摘要】：目的:观察复方蜈蚣颗粒口服在慢性跟骨骨髓炎腓肠神经营养血管皮瓣转移术后的临床疗效。方法:2012年1月至2015年12月于山东省文登整骨医院收住的诊断为慢性跟骨骨髓炎的连续性病例,共46例,脱落3例,纳入本研究43例,男性34例,女性9例;年龄22-64岁。根据患者在腓肠神经营养血管皮瓣转移术后是否冲服复方蜈蚣颗粒分为两组,冲服者入试验组,未冲服者入对照组。收集术后第1、5、15天患者疼痛评分;第15天患者切口口愈合情况;第1周,1、6个月感染指标;末次随访时骨髓炎复发情况及患者满意度;末次随访时AOFAS踝-后足评分进行疗效评价。结果:随访时间9-13个月,平均11.3个月。两组患者术后第1天疼痛评分无明显差异,第5、15天疼痛评分实验组优于对照组;术后第15天刀口愈合试验组优于对照组;术后1周、第1个月感染指标试验组优于对照组,第6个月感染指标两组之间无明显差异;末次随访试验组复发率、满意度均优于对照组;末次随访AOFAS踝-后足评分试验组优于对照组。结论:复方蜈蚣颗粒能改善患者术后疼痛,促进术后切口愈合,改善患者短期骨髓炎复发率及患者满意度,改善踝-后足的功能,是辅助腓肠神经营养血管皮瓣转移术治疗慢性跟骨骨髓炎安全有效的药物。
[Abstract]:Objective: to observe the clinical effect of compound centipede granule after sural neurovascular flap transfer in chronic calcaneal osteomyelitis. Methods: from January 2012 to December 2015, 46 consecutive cases of chronic calcaneal osteomyelitis were diagnosed in Wendeng whole bone hospital of Shandong province, including 43 cases of male 34 cases and 9 cases of female aged 22-64 years. Patients were divided into two groups according to whether to take compound centipede granules after sural neurovascular flap transfer. The pain scores of the patients were collected on the 15th day after operation, the wound healing on the 15th day, the infection index at the 1st week and the 6th month, the recurrence of osteomyelitis and the satisfaction degree of the patients at the last follow-up, and the AOFAS ankle-hind foot score at the last follow-up to evaluate the curative effect. Results: the follow-up time was 9-13 months (mean 11.3 months). There was no significant difference in pain score between the two groups on the first day after operation. The pain score of the experimental group was better than that of the control group on the 15th day after operation; the experimental group was superior to the control group on the 15th day after operation; the infection index test group was superior to the control group at 1 week and the first month after operation. There was no significant difference in infection index between the two groups at the 6th month; the recurrence rate and satisfaction degree of the last follow-up group were better than those of the control group; the AOFAS ankle-hind foot score test group at the last follow-up was superior to the control group. Conclusion: compound centipede granule can improve postoperative pain, promote postoperative wound healing, improve the recurrence rate and satisfaction of patients with short-term osteomyelitis, and improve the function of ankle-hind foot. It is a safe and effective drug for the treatment of chronic calcaneal osteomyelitis with sural neurovascular flap transfer.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R687

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