胸腰段血管瘤有限元模型建立及生物力学分析

发布时间：2018-08-04 15:40

【摘要】：背景:关于胸椎段肿瘤生物力学方面的研究比较多,但是有关有限元分析胸腰段椎体血管瘤骨折风险的研究不多。目的:建立胸腰段椎体血管瘤有限元模型,分析其生物力学分布特点,评估脊椎血管瘤的骨折风险。方法:建立T_(12)-L_2椎体的正常椎体、血管瘤椎体(血管瘤占椎体松质骨比例分别为20%,40%,60%,80%)、骨水泥填充椎体三维有限元模型,并进行力学分析。分别予以600 N垂直静态压力下正常椎体、血管瘤椎体、骨水泥填充的椎体等效应力分布及特点。结果与结论:(1)建立了有效的T_(12)-L_2椎体有限元模型。在静态压力作用下3组模型L_1椎体皮质骨应力传导无明显差异,应力最大部均出现在椎弓根基底部、关节突关节及峡部;(2)在骨皮质完整情况下,椎体血管瘤占椎体松质骨20%-40%时病变椎体与正常椎体应力分布无统计学差异;当比例为60%-80%时,病变椎体与正常椎体应力分布有统计学差异;(3)建立的胸腰段三维有限元模型具有可用性;生物力学实验显示,椎体皮质骨完整性、松质骨破坏比例是椎体血管瘤骨折风险关键因素。
[Abstract]:Background: much research has been done on the biomechanics of thoracic vertebrae, but there are few studies on the risk of thoracolumbar vertebral hemangioma fracture by finite element analysis. Objective: to establish a finite element model of thoracolumbar vertebral hemangioma, analyze its biomechanical distribution and evaluate the fracture risk of spinal hemangioma. Methods: the normal vertebral body of T _ (12) -L _ 2 was established. The vertebral body of hemangioma (the proportion of hemangioma to cancellous bone of vertebral body was 204040%), the three-dimensional finite element model of vertebral body was filled with bone cement, and the mechanical analysis was carried out. The distribution and characteristics of equivalent stress of normal vertebral body, hemangioma vertebral body and bone cement filled vertebral body were given under 600 N vertical static pressure. Results and conclusions: (1) an effective finite element model of T _ (12) -L _ 2 vertebrae was established. Under static pressure, there was no significant difference in stress conduction of L1 vertebra cortical bone in the three groups. The maximum stress appeared at the base of pedicle, articular process and isthmus. (2) under the condition of complete bone cortex, the stress of the three groups appeared at the base of pedicle, articular process and isthmus. There was no significant difference in stress distribution between vertebral body and normal vertebra when 20% -40% of vertebral cancellous bone was occupied by vertebral hemangioma, and when the proportion was 60% -80%, there was no significant difference in stress distribution between vertebral body and normal vertebral body. The stress distribution of diseased vertebral body and normal vertebral body is statistically different. (3) the three-dimensional finite element model of thoracolumbar segment is available; the biomechanical experiment shows that the cortical bone integrity of vertebral body is intact. The ratio of cancellous bone destruction is a key risk factor for vertebral hemangioma fracture.
【作者单位】：新疆医科大学附属肿瘤医院骨与软组织病区;
【基金】：国家自然科学基金项目(81360282)~~
【分类号】：R738

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